EnglishABSTRACT: While the role of the blood-brain barrier (BBB) is increasingly recognized in the (development of treatments targeting neurodegenerative disorders, to date, few strategies exist that enable drug delivery of non-BBB crossing molecules directly to their site of action, the brain. However, the recent advent of Nanomedicines may provide a potent tool to implement CNS targeted delivery of active compounds. Approaches for BBB crossing are deeply investigated in relation to the pathology: among the main important diseases of the CNS, this review focuses on the application of nanomedicines to neurodegenerative disorders (Alzheimer, Parkinson and Huntington's Disease) and to other brain pathologies as epilepsy, infectious diseases, multiple sclerosis, lysosomal storage disorders, strokes.
Nanoparticle transport across the blood brain barrier / Grabrucker, Andreas M.; Ruozi, Barbara; Belletti, Daniela; Pederzoli, Francesca; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni. - In: TISSUE BARRIERS. - ISSN 2168-8362. - STAMPA. - 4:1(2016), pp. 1-18.
| Data di pubblicazione: | 2016 |
| Titolo: | Nanoparticle transport across the blood brain barrier |
| Autore/i: | Grabrucker, Andreas M.; Ruozi, Barbara; Belletti, Daniela; Pederzoli, Francesca; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1080/21688370.2016.1153568 |
| Rivista: | |
| Volume: | 4 |
| Fascicolo: | 1 |
| Pagina iniziale: | 1 |
| Pagina finale: | 18 |
| Codice identificativo ISI: | WOS:000378395700010 |
| Codice identificativo Scopus: | 2-s2.0-84981214261 |
| Codice identificativo Pubmed: | 27141426 |
| Citazione: | Nanoparticle transport across the blood brain barrier / Grabrucker, Andreas M.; Ruozi, Barbara; Belletti, Daniela; Pederzoli, Francesca; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni. - In: TISSUE BARRIERS. - ISSN 2168-8362. - STAMPA. - 4:1(2016), pp. 1-18. |
| Tipologia | Articolo su rivista |
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| proof Tissue Barriers 2016.pdf | Post-print dell'autore (bozza post referaggio) | Open Access Visualizza/Apri |
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