Prevention is the main strategy in order to reduce colorectal cancer incidence and mortality. It can be accomplished through primary prevention, using measures affecting factors known to confer higher risk of colorectal cancer, or through secondary prevention, aimed at early diagnosis of cancer or preneoplastic lesions in groups of subjects at increased risk of cancer. Although primary prevention should be the goal for future years, because it acts on the probable causes of colorectal cancer, at present it seems that secondary prevention is more effective on colorectal cancer survival, and the approaches which have yielded the most satisfying results, in terms of reduced mortality for cancer, are those aimed at detecting preneoplastic lesions, or cancer at an early stage in selected groups of subjects at average or increased risk of colorectal cancer. These groups are subjects aged 50 years or older, affected individuals (gene carriers) or family members of hereditary colorectal cancer syndromes (i.e., Lynch syndrome and familial adenomatous polyposis), and patients with inflammatory bowel diseases. The most effective procedures used, though with some drawbacks, are fecal occult blood tests and colonoscopy. Future research should be addressed to find new approaches that will render preventive strategies more acceptable for the population, and more cost-effective.

Prevention of colorectal cancer: How many tools do we have in our basket? / Roncucci, Luca; Mariani, Francesco. - In: EUROPEAN JOURNAL OF INTERNAL MEDICINE. - ISSN 0953-6205. - 26:10(2015), pp. 752-756. [10.1016/j.ejim.2015.08.019]

Prevention of colorectal cancer: How many tools do we have in our basket?

RONCUCCI, Luca;MARIANI, Francesco
2015

Abstract

Prevention is the main strategy in order to reduce colorectal cancer incidence and mortality. It can be accomplished through primary prevention, using measures affecting factors known to confer higher risk of colorectal cancer, or through secondary prevention, aimed at early diagnosis of cancer or preneoplastic lesions in groups of subjects at increased risk of cancer. Although primary prevention should be the goal for future years, because it acts on the probable causes of colorectal cancer, at present it seems that secondary prevention is more effective on colorectal cancer survival, and the approaches which have yielded the most satisfying results, in terms of reduced mortality for cancer, are those aimed at detecting preneoplastic lesions, or cancer at an early stage in selected groups of subjects at average or increased risk of colorectal cancer. These groups are subjects aged 50 years or older, affected individuals (gene carriers) or family members of hereditary colorectal cancer syndromes (i.e., Lynch syndrome and familial adenomatous polyposis), and patients with inflammatory bowel diseases. The most effective procedures used, though with some drawbacks, are fecal occult blood tests and colonoscopy. Future research should be addressed to find new approaches that will render preventive strategies more acceptable for the population, and more cost-effective.
2015
21-ott-2015
26
10
752
756
Prevention of colorectal cancer: How many tools do we have in our basket? / Roncucci, Luca; Mariani, Francesco. - In: EUROPEAN JOURNAL OF INTERNAL MEDICINE. - ISSN 0953-6205. - 26:10(2015), pp. 752-756. [10.1016/j.ejim.2015.08.019]
Roncucci, Luca; Mariani, Francesco
File in questo prodotto:
File Dimensione Formato  
EJIM Roncucci 2015.pdf

Accesso riservato

Descrizione: Article in press
Tipologia: Versione pubblicata dall'editore
Dimensione 238.74 kB
Formato Adobe PDF
238.74 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
VOR_Prevention of colorectal cancer.pdf

Accesso riservato

Tipologia: Versione pubblicata dall'editore
Dimensione 257.05 kB
Formato Adobe PDF
257.05 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1114500
Citazioni
  • ???jsp.display-item.citation.pmc??? 44
  • Scopus 99
  • ???jsp.display-item.citation.isi??? 95
social impact