Two series of glasses of general formula (2-p) SiO21.1Na2OCaOpP2O5xZnO ( p ¼ 0.10, 0.20; x ¼ 0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblastlike cells behavior when cultured on them. The resulted good cell adhesion and growth, along with nonsignificant changes of the focal contacts, allow the authors to indicate HZ5 and HP5Z5 glasses as the ones having optimal ratio of Zn/P to maintain acceptable cell behavior, comparable to the bioactive glass (Bioglass) used as a control; results are also rationalized by means of three-dimensional models derived by molecular dynamic simulations, with decomposition and conversion rates optimized with respect to the parent Hench’s Bioglass
Zinc-releasing silicate-bioglasses modulated Bone Cells Activity / Lusvardi, Gigliola; Malavasi, Gianluca; Menabue, Ledi; Menziani, Maria Cristina; Segre, Ulderico; V., Aina; C., Morterra; M. F., Cannas. - (2005). (Intervento presentato al convegno 30th annual Meeting & Exposition of Soc. for Biomaterials 2005 Ann. Meeting tenutosi a Memphys (USA) nel 04/27/2005).
Zinc-releasing silicate-bioglasses modulated Bone Cells Activity
LUSVARDI, Gigliola;MALAVASI, Gianluca;MENABUE, Ledi;MENZIANI, Maria Cristina;SEGRE, Ulderico;
2005
Abstract
Two series of glasses of general formula (2-p) SiO21.1Na2OCaOpP2O5xZnO ( p ¼ 0.10, 0.20; x ¼ 0.0, 0.16, 0.35, and 0.78) have been analyzed for physico-chemical surface features before and after contact with simulated body fluid, morphological characteristics, and osteoblastlike cells behavior when cultured on them. The resulted good cell adhesion and growth, along with nonsignificant changes of the focal contacts, allow the authors to indicate HZ5 and HP5Z5 glasses as the ones having optimal ratio of Zn/P to maintain acceptable cell behavior, comparable to the bioactive glass (Bioglass) used as a control; results are also rationalized by means of three-dimensional models derived by molecular dynamic simulations, with decomposition and conversion rates optimized with respect to the parent Hench’s Bioglass
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