Objective: To examine functional connectivity within the basal ganglia network (BGN) in a group of cognitively normal patients with early Parkinson disease (PD) on and off medication compared to age- and sex-matched healthy controls (HC), and to validate the findings in a separate cohort of participants with PD. Methods: Participants were scanned with resting-state fMRI (RS-fMRI) at 3T field strength. Resting-state networks were isolated using independent component analysis. A BGN template was derived from 80 elderly HC participants. BGN maps were compared between 19 patients with PD on and off medication in the discovery group and 19 age- and sex-matched controls to identify a threshold for optimal group separation. The threshold was applied to 13 patients with PD (including 5 drug-naive) in the validation group to establish reproducibility of findings. Results: Participants with PD showed reduced functional connectivity with the BGN in a wide range of areas. Administration of medication significantly improved connectivity. Average BGN connectivity differentiated participants with PD from controls with 100% sensitivity and 89.5% specificity. The connectivity threshold was tested on the validation cohort and achieved 85% accuracy. Conclusions: We demonstrate that resting functional connectivity, measured with MRI using an observer-independent method, is reproducibly reduced in the BGN in cognitively intact patients with PD, and increases upon administration of dopaminergic medication. Our results hold promise for RS-fMRI connectivity as a biomarker in early PD. Classification of evidence: This study provides Class III evidence that average connectivity in the BGN as measured by RS-fMRI distinguishes patients with PD from age- and sex-matched controls. © 2014 American Academy of Neurology.

Functional connectivity in the basal ganglia network differentiates PD patients from controls / Szewczyk Krolikowski, Konrad; Menke, Ricarda A. L.; Rolinski, Michal; Duff, Eugene; Salimi Khorshidi, Gholamreza; Filippini, Nicola; Zamboni, Giovanna; Hu, Michele T. M.; Mackay, Clare E.. - In: NEUROLOGY. - ISSN 0028-3878. - 83:(2014), pp. 208-214. [10.1212/WNL.0000000000000592]

Functional connectivity in the basal ganglia network differentiates PD patients from controls

ZAMBONI, Giovanna;
2014-01-01

Abstract

Objective: To examine functional connectivity within the basal ganglia network (BGN) in a group of cognitively normal patients with early Parkinson disease (PD) on and off medication compared to age- and sex-matched healthy controls (HC), and to validate the findings in a separate cohort of participants with PD. Methods: Participants were scanned with resting-state fMRI (RS-fMRI) at 3T field strength. Resting-state networks were isolated using independent component analysis. A BGN template was derived from 80 elderly HC participants. BGN maps were compared between 19 patients with PD on and off medication in the discovery group and 19 age- and sex-matched controls to identify a threshold for optimal group separation. The threshold was applied to 13 patients with PD (including 5 drug-naive) in the validation group to establish reproducibility of findings. Results: Participants with PD showed reduced functional connectivity with the BGN in a wide range of areas. Administration of medication significantly improved connectivity. Average BGN connectivity differentiated participants with PD from controls with 100% sensitivity and 89.5% specificity. The connectivity threshold was tested on the validation cohort and achieved 85% accuracy. Conclusions: We demonstrate that resting functional connectivity, measured with MRI using an observer-independent method, is reproducibly reduced in the BGN in cognitively intact patients with PD, and increases upon administration of dopaminergic medication. Our results hold promise for RS-fMRI connectivity as a biomarker in early PD. Classification of evidence: This study provides Class III evidence that average connectivity in the BGN as measured by RS-fMRI distinguishes patients with PD from age- and sex-matched controls. © 2014 American Academy of Neurology.
83
208
214
Functional connectivity in the basal ganglia network differentiates PD patients from controls / Szewczyk Krolikowski, Konrad; Menke, Ricarda A. L.; Rolinski, Michal; Duff, Eugene; Salimi Khorshidi, Gholamreza; Filippini, Nicola; Zamboni, Giovanna; Hu, Michele T. M.; Mackay, Clare E.. - In: NEUROLOGY. - ISSN 0028-3878. - 83:(2014), pp. 208-214. [10.1212/WNL.0000000000000592]
Szewczyk Krolikowski, Konrad; Menke, Ricarda A. L.; Rolinski, Michal; Duff, Eugene; Salimi Khorshidi, Gholamreza; Filippini, Nicola; Zamboni, Giovanna; Hu, Michele T. M.; Mackay, Clare E.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1108774
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