INTRODUCTION: Telomeres may be considered markers of biological aging, shorter telomere length is associated with some age-related diseases; in several studies short telomere length has also been associated to obesity in adults and adolescents. However the relationship between telomere complex functions and obesity is still not clear. Aim of the study was to assess telomere length (TL) in adults' obese subjects before and after weight loss obtained by placement of bioenteric intragastric balloon (BIB) for 6months. METHODS: We enrolled 42 obese subjects before and after BIB placement as weight loss intervention. Blood samples were collected in order to obtain DNA from leukocyte to measure TL by quantitative PCR. RESULTS: Data were analyzed only in 37 subjects with complete data; all presented important body weight loss (124.06±26.7 vs 105.40±23.14, p<0.001) and more interesting they presented a significant increase in TL (3.58±0.83 vs 5.61±3.29, p<0.001). Moreover we observed a significant positive correlation between TL elongation and weight loss (r=0.44, p=0.007) as well as an inverse correlation between TL at baseline and TL elongation (r=-0.35, p=0.03).The predictors of TL elongation were once again weight loss and short TL at baseline (respectively p=0.007 and p=0.003). CONCLUSIONS: Our study shows that weight loss is associated to telomere lengthening in a positive correlation: the greater weight loss the greater telomere lengthening; moreover telomere lengthening is more significant in those subjects with shortest telomeres at baseline.

Introduction: Telomeres may be considered markers of biological aging, shorter telomere length is associated with some age-related diseases; in several studies short telomere length has also been associated to obesity in adults and adolescents. However the relationship between telomere complex functions and obesity is still not clear. Aim of the study was to assess telomere length (TL) in adults' obese subjects before and after weight loss obtained by placement of bioenteric intragastric balloon (BIB) for 6 months. Methods: We enrolled 42 obese subjects before and after BIB placement as weight loss intervention. Blood samples were collected in order to obtain DNA from leukocyte to measure TL by quantitative PCR. Results: Data were analyzed only in 37 subjects with complete data; all presented important body weight loss (124.06 ± 26.7 vs 105.40 ± 23.14, p < 0.001) and more interesting they presented a significant increase in TL (3.58 ± 0.83 vs 5.61 ± 3.29, p < 0.001). Moreover we observed a significant positive correlation between TL elongation and weight loss (r = 0.44, p = 0.007) as well as an inverse correlation between TL at baseline and TL elongation (r = - 0.35, p = 0.03).The predictors of TL elongation were once again weight loss and short TL at baseline (respectively p = 0.007 and p = 0.003). Conclusions: Our study shows that weight loss is associated to telomere lengthening in a positive correlation: the greater weight loss the greater telomere lengthening; moreover telomere lengthening is more significant in those subjects with shortest telomeres at baseline.

Telomere length elongation after weight loss intervention in obese adults / Carulli, Lucia; Anzivino, Claudia; Baldelli, Enrica; Zenobii, Mf; Rocchi, Mb; Bertolotti, Marco. - In: MOLECULAR GENETICS AND METABOLISM. - ISSN 1096-7206. - 118:2(2016), pp. 138-142. [10.1016/j.ymgme.2016.04.003]

Telomere length elongation after weight loss intervention in obese adults

CARULLI, Lucia;ANZIVINO, Claudia;BALDELLI, Enrica;BERTOLOTTI, Marco
2016

Abstract

Introduction: Telomeres may be considered markers of biological aging, shorter telomere length is associated with some age-related diseases; in several studies short telomere length has also been associated to obesity in adults and adolescents. However the relationship between telomere complex functions and obesity is still not clear. Aim of the study was to assess telomere length (TL) in adults' obese subjects before and after weight loss obtained by placement of bioenteric intragastric balloon (BIB) for 6 months. Methods: We enrolled 42 obese subjects before and after BIB placement as weight loss intervention. Blood samples were collected in order to obtain DNA from leukocyte to measure TL by quantitative PCR. Results: Data were analyzed only in 37 subjects with complete data; all presented important body weight loss (124.06 ± 26.7 vs 105.40 ± 23.14, p < 0.001) and more interesting they presented a significant increase in TL (3.58 ± 0.83 vs 5.61 ± 3.29, p < 0.001). Moreover we observed a significant positive correlation between TL elongation and weight loss (r = 0.44, p = 0.007) as well as an inverse correlation between TL at baseline and TL elongation (r = - 0.35, p = 0.03).The predictors of TL elongation were once again weight loss and short TL at baseline (respectively p = 0.007 and p = 0.003). Conclusions: Our study shows that weight loss is associated to telomere lengthening in a positive correlation: the greater weight loss the greater telomere lengthening; moreover telomere lengthening is more significant in those subjects with shortest telomeres at baseline.
2016
22-apr-2016
118
2
138
142
Telomere length elongation after weight loss intervention in obese adults / Carulli, Lucia; Anzivino, Claudia; Baldelli, Enrica; Zenobii, Mf; Rocchi, Mb; Bertolotti, Marco. - In: MOLECULAR GENETICS AND METABOLISM. - ISSN 1096-7206. - 118:2(2016), pp. 138-142. [10.1016/j.ymgme.2016.04.003]
Carulli, Lucia; Anzivino, Claudia; Baldelli, Enrica; Zenobii, Mf; Rocchi, Mb; Bertolotti, Marco
File in questo prodotto:
File Dimensione Formato  
tel e obesi.pdf

Accesso riservato

Tipologia: Versione pubblicata dall'editore
Dimensione 284.63 kB
Formato Adobe PDF
284.63 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1108689
Citazioni
  • ???jsp.display-item.citation.pmc??? 26
  • Scopus 47
  • ???jsp.display-item.citation.isi??? 45
social impact