The present study aimed to investigate whether microbial invasion of the amniotic cavity affects maternal plasma or placental immunoreactive corticotrophin releasing factor (ir-CRF) concentrations in pregnant women with pre-term or term labour. A cross-sectional study was conducted collecting blood samples in: (I) women with pre-term labour and intact membranes (25-36 weeks), with or without microbial invasion of the amniotic cavity (subdivided into three groups: IA, no microbial invasion of the amniotic cavity, delivery at term, n = 54; group IB, delivery < 48 h, no microbial invasion of the amniotic cavity, n = IO; group IC, delivery < 48 h, microbial invasion of the amniotic cavity, n = 8); (2) women at term, not in labour and without microbial invasion of the amniotic cavity (n = 15); (3) women in spontaneous active labour at term without (A) (n = 55) or with (B) (n = 16) microbial invasion of the amniotic cavity; and (4) healthy women not in labour at 25-36 weeks of gestation (n = 25). Specimens of trophoblast tissue were collected from pregnant women with pre-term labour (no microbial invasion of the amniotic cavity, n = 6; microbial invasion of the amniotic cavity, n = 4) or delivering at term (no microbial invasion of the amniotic cavity, n = 8; microbial invasion of the amniotic cavity, n = 4). A specific radioimmunoassay on acidic extracts of plasma or placental specimens was used. Patients with pre-term labour showed higher plasma ir-CRF concentration than healthy women at the same gestational age or at term not in labour, and those with microbial invasion of the amniotic cavity, had higher plasma ir-CRF concentrations than the ones without microbial invasion of the amniotic cavity (P < 0.05). Term labour was associated with elevated plasma ir-CRF concentrations, not affected by, the presence or absence of microbial invasion of the amniotic cavity. Placental ir-CRF concentrations in women with pre-term labour, in absence of microbial invasion of the amniotic cavity, mere significantly lower than in women with pre-term labour associated with microbial invasion of the amniotic cavity (P < 0.05). These findings showing a different pattern of maternal and placenta ir-CRF concentrations between pre-term labour with ol without microbial invasion of the amniotic cavity, support the hypothesis of an impact of infection on neuroendocrine activity, of human placenta.

The present study aimed to investigate whether microbial invasion of the amniotic cavity affects maternal plasma or placental immunoreactive corticotrophin releasing factor (ir-CRF) concentrations in pregnant women with pre-term or term labour. A cross-sectional study was conducted collecting blood samples in: (1) women with pre-term labour and intact membranes (25-36 weeks), with or without microbial invasion of the amniotic cavity (subdivided into three groups: 1A, no microbial invasion of the amniotic cavity, delivery at term, n = 54; group 1B, delivery < 48h, no microbial invasion of the amniotic cavity, n = 10; group 1C, delivery < 48 h, microbial invasion of the amniotic cavity, n = 8); (2) women at term, not in labour and without microbial invasion of the amniotic cavity (n = 15); (3) women in spontaneous active labour at term without (A) (n = 55) or with (B) (n = 16) microbial invasion of the amniotic cavity; and (4) healthy women not in labour at 25-36 weeks ofgestation (n = 25). Specimens of trophoblast tissue were collected from pregnant women with pre-term labour (no microbial invasion of the amniotic cavity, n = 6; microbial invasion of the amniotic cavity, n = 4) or delivering at term (no microbial invasion of the amniotic cavity, n = 8; microbial invasion of the amniotic cavity, n = 4). A specific radioimmunoassay on acidic extracts of plasma or placental specimens was used. Patients with pre-term labour showed higher plasma ir-CRF concentration than healthy women at the same gestational age or at term not in labour, and those with microbial invasion of the amniotic cavity had higher plasma ir-CRF concentrations than the ones without microbial invasion of the amniotic cavity (P < 0.05). Term labour was associated with elevated plasma ir-CRF concentrations, not affected by the presence or absence of microbial invasion of the amniotic cavity. Placental ir-CRF concentrations in women with pre-term labour, in absence of microbial invasion of the amniotic vacity, were significantly lower than in women with pre-term labour associated with microbial invasion of the amniotic vacity (P < 0.05). These findings showing a different pattern of maternal and placenta ir-CRF concentrations between pre-term labour with or without microbial invasion of the amniotic cavity support the hypothesis of an impact of infection on neuroendocrine activity of human placenta. © 1995.

Maternal plasma and placental immunoreactive corticotrophin-releasing factor concentrations in infection-associated term and pre-term delivery / Petraglia, F; Aguzzoli, L.; Florio, P.; Baumann, P.; Genazzani, Alessandro; Di Carlo, C.; Romero, R.. - In: PLACENTA. - ISSN 0143-4004. - STAMPA. - 16:(1995), pp. 157-164. [10.1016/0143-4004(95)90004-7]

Maternal plasma and placental immunoreactive corticotrophin-releasing factor concentrations in infection-associated term and pre-term delivery

GENAZZANI, Alessandro;
1995

Abstract

The present study aimed to investigate whether microbial invasion of the amniotic cavity affects maternal plasma or placental immunoreactive corticotrophin releasing factor (ir-CRF) concentrations in pregnant women with pre-term or term labour. A cross-sectional study was conducted collecting blood samples in: (1) women with pre-term labour and intact membranes (25-36 weeks), with or without microbial invasion of the amniotic cavity (subdivided into three groups: 1A, no microbial invasion of the amniotic cavity, delivery at term, n = 54; group 1B, delivery < 48h, no microbial invasion of the amniotic cavity, n = 10; group 1C, delivery < 48 h, microbial invasion of the amniotic cavity, n = 8); (2) women at term, not in labour and without microbial invasion of the amniotic cavity (n = 15); (3) women in spontaneous active labour at term without (A) (n = 55) or with (B) (n = 16) microbial invasion of the amniotic cavity; and (4) healthy women not in labour at 25-36 weeks ofgestation (n = 25). Specimens of trophoblast tissue were collected from pregnant women with pre-term labour (no microbial invasion of the amniotic cavity, n = 6; microbial invasion of the amniotic cavity, n = 4) or delivering at term (no microbial invasion of the amniotic cavity, n = 8; microbial invasion of the amniotic cavity, n = 4). A specific radioimmunoassay on acidic extracts of plasma or placental specimens was used. Patients with pre-term labour showed higher plasma ir-CRF concentration than healthy women at the same gestational age or at term not in labour, and those with microbial invasion of the amniotic cavity had higher plasma ir-CRF concentrations than the ones without microbial invasion of the amniotic cavity (P < 0.05). Term labour was associated with elevated plasma ir-CRF concentrations, not affected by the presence or absence of microbial invasion of the amniotic cavity. Placental ir-CRF concentrations in women with pre-term labour, in absence of microbial invasion of the amniotic vacity, were significantly lower than in women with pre-term labour associated with microbial invasion of the amniotic vacity (P < 0.05). These findings showing a different pattern of maternal and placenta ir-CRF concentrations between pre-term labour with or without microbial invasion of the amniotic cavity support the hypothesis of an impact of infection on neuroendocrine activity of human placenta. © 1995.
1995
16
157
164
Maternal plasma and placental immunoreactive corticotrophin-releasing factor concentrations in infection-associated term and pre-term delivery / Petraglia, F; Aguzzoli, L.; Florio, P.; Baumann, P.; Genazzani, Alessandro; Di Carlo, C.; Romero, R.. - In: PLACENTA. - ISSN 0143-4004. - STAMPA. - 16:(1995), pp. 157-164. [10.1016/0143-4004(95)90004-7]
Petraglia, F; Aguzzoli, L.; Florio, P.; Baumann, P.; Genazzani, Alessandro; Di Carlo, C.; Romero, R.
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