Background: Glioblastoma multiforme (GBM) is the deadliest malignant primary brain tumor in adults. GBM develops primarily in the cerebral hemispheres but can develop in other parts of the central nervous system. Its congenital variant is a very rare disease with few cases described in literature. Case presentation: We describe the case of a patient with congenital GBM who developed eruptive disseminated Spitz nevi (EDSN) after chemotherapy. Few cases of EDSN have been described in literature and this rare clinical variant, which occurs predominantly in adults, is characterized by multiple Spitz nevi in the trunk, buttocks, elbows and knees. There is no satisfactory treatment for EDSN and the best therapeutic choice is considered the clinical observation of melanocytic lesions. Conclusion: We recommend a close follow-up of these patients with clinical observation, dermoscopy and reflectance confocal microscopy (RCM). However, we suggest a surgical excision of the lesions suspected of being malignant.

Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi / Mandel, Victor Desmond; Persechino, Flavia; Berardi, Alberto; Ponti, Giovanni; Ciardo, Silvana; Rossi, Cecilia; Pellacani, Giovanni; Farnetani, Francesca. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1720-8424. - ELETTRONICO. - 42:1(2016), pp. 1-5. [10.1186/s13052-016-0260-9]

Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi

MANDEL, Victor Desmond
;
PERSECHINO, Flavia;BERARDI, Alberto;PONTI, Giovanni;ROSSI, Cecilia;PELLACANI, Giovanni;FARNETANI, Francesca
2016

Abstract

Background: Glioblastoma multiforme (GBM) is the deadliest malignant primary brain tumor in adults. GBM develops primarily in the cerebral hemispheres but can develop in other parts of the central nervous system. Its congenital variant is a very rare disease with few cases described in literature. Case presentation: We describe the case of a patient with congenital GBM who developed eruptive disseminated Spitz nevi (EDSN) after chemotherapy. Few cases of EDSN have been described in literature and this rare clinical variant, which occurs predominantly in adults, is characterized by multiple Spitz nevi in the trunk, buttocks, elbows and knees. There is no satisfactory treatment for EDSN and the best therapeutic choice is considered the clinical observation of melanocytic lesions. Conclusion: We recommend a close follow-up of these patients with clinical observation, dermoscopy and reflectance confocal microscopy (RCM). However, we suggest a surgical excision of the lesions suspected of being malignant.
14-mag-2016
42
1
1
5
Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi / Mandel, Victor Desmond; Persechino, Flavia; Berardi, Alberto; Ponti, Giovanni; Ciardo, Silvana; Rossi, Cecilia; Pellacani, Giovanni; Farnetani, Francesca. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1720-8424. - ELETTRONICO. - 42:1(2016), pp. 1-5. [10.1186/s13052-016-0260-9]
Mandel, Victor Desmond; Persechino, Flavia; Berardi, Alberto; Ponti, Giovanni; Ciardo, Silvana; Rossi, Cecilia; Pellacani, Giovanni; Farnetani, Francesca
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1107396
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