Background: Glioblastoma multiforme (GBM) is the deadliest malignant primary brain tumor in adults. GBM develops primarily in the cerebral hemispheres but can develop in other parts of the central nervous system. Its congenital variant is a very rare disease with few cases described in literature. Case presentation: We describe the case of a patient with congenital GBM who developed eruptive disseminated Spitz nevi (EDSN) after chemotherapy. Few cases of EDSN have been described in literature and this rare clinical variant, which occurs predominantly in adults, is characterized by multiple Spitz nevi in the trunk, buttocks, elbows and knees. There is no satisfactory treatment for EDSN and the best therapeutic choice is considered the clinical observation of melanocytic lesions. Conclusion: We recommend a close follow-up of these patients with clinical observation, dermoscopy and reflectance confocal microscopy (RCM). However, we suggest a surgical excision of the lesions suspected of being malignant.

Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi / Mandel, Victor Desmond; Persechino, Flavia; Berardi, Alberto; Ponti, Giovanni; Ciardo, Silvana; Rossi, Cecilia; Pellacani, Giovanni; Farnetani, Francesca. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1720-8424. - ELETTRONICO. - 42:1(2016), pp. 1-5. [10.1186/s13052-016-0260-9]

Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi

MANDEL, Victor Desmond
;
PERSECHINO, Flavia;BERARDI, Alberto;PONTI, Giovanni;ROSSI, Cecilia;PELLACANI, Giovanni;FARNETANI, Francesca
2016

Abstract

Background: Glioblastoma multiforme (GBM) is the deadliest malignant primary brain tumor in adults. GBM develops primarily in the cerebral hemispheres but can develop in other parts of the central nervous system. Its congenital variant is a very rare disease with few cases described in literature. Case presentation: We describe the case of a patient with congenital GBM who developed eruptive disseminated Spitz nevi (EDSN) after chemotherapy. Few cases of EDSN have been described in literature and this rare clinical variant, which occurs predominantly in adults, is characterized by multiple Spitz nevi in the trunk, buttocks, elbows and knees. There is no satisfactory treatment for EDSN and the best therapeutic choice is considered the clinical observation of melanocytic lesions. Conclusion: We recommend a close follow-up of these patients with clinical observation, dermoscopy and reflectance confocal microscopy (RCM). However, we suggest a surgical excision of the lesions suspected of being malignant.
2016
14-mag-2016
42
1
1
5
Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi / Mandel, Victor Desmond; Persechino, Flavia; Berardi, Alberto; Ponti, Giovanni; Ciardo, Silvana; Rossi, Cecilia; Pellacani, Giovanni; Farnetani, Francesca. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1720-8424. - ELETTRONICO. - 42:1(2016), pp. 1-5. [10.1186/s13052-016-0260-9]
Mandel, Victor Desmond; Persechino, Flavia; Berardi, Alberto; Ponti, Giovanni; Ciardo, Silvana; Rossi, Cecilia; Pellacani, Giovanni; Farnetani, Francesca
File in questo prodotto:
File Dimensione Formato  
Congenital Glioblastoma multiforme and eruptive disseminated Spitz nevi.pdf

Open access

Descrizione: Articolo principale
Tipologia: Versione pubblicata dall'editore
Dimensione 1.73 MB
Formato Adobe PDF
1.73 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1107396
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 9
social impact