Tonsillectomy has been considered a treatment for IgA nephropathy (IgAN). It is aimed at removing a source of pathogens, reducing mucosa-associated lymphoid tissue and decreasing polymeric IgA synthesis. However, its beneficial effect is still controversial. In Asia, favorable outcomes have been claimed mostly in association with corticosteroids. In Europe, small, single-center uncontrolled studies have failed to show benefits.
Tonsillectomy in a European Cohort of 1,147 Patients with IgA Nephropathy / Feehally, John; Coppo, Rosanna; Troyanov, Stéphan; Bellur, Shubha S; Cattran, Daniel; Cook, Terence; Roberts, Ian S. D; Verhave, Jacobien C; Camilla, Roberta; Vergano, Luca; Egido, Jesus; Wiecek, Andrzej; Karkoszka, Henryk; Tesar, Vladimir; Maixnerova, Dita; Ots Rosenberg, Mai; Quaglia, Marco; Rollino, Cristiana; Magistroni, Riccardo; Cusinato, Stefano; Cravero, Raffaella; Peruzzi, Licia; Lundberg, Sigrid; Gesualdo, Loreto; Cancarini, Giovanni; Feriozzi, Sandro; Ferrario, Franco. - In: NEPHRON JOURNALS. - ISSN 1660-8151. - 132:1(2016), pp. 15-24. [10.1159/000441852]
Tonsillectomy in a European Cohort of 1,147 Patients with IgA Nephropathy
MAGISTRONI, Riccardo;
2016
Abstract
Tonsillectomy has been considered a treatment for IgA nephropathy (IgAN). It is aimed at removing a source of pathogens, reducing mucosa-associated lymphoid tissue and decreasing polymeric IgA synthesis. However, its beneficial effect is still controversial. In Asia, favorable outcomes have been claimed mostly in association with corticosteroids. In Europe, small, single-center uncontrolled studies have failed to show benefits.
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