Several phenotypic, molecular and chromosomal markers of chronic lymphocytic leukemia (CLL) cells have been identified that are significantly associated with patient prognosis.1, 2, 3, 4, 5, 6 However, these markers used singularly are inaccurate predictors of outcome for individual patients. Recent efforts have focused on combining markers to predict either treatment-free survival (TFS)4, 7, 8 or overall survival (OS),9, 10, 11 however, further effort is worthwhile to determine how to combine prognostic parameters, optimize risk stratification, simplify calculations and/or identify new prognostic variables.
A progression-risk score to predict treatment-free survival for early stage chronic lymphocytic leukemia patients / Gentile, M., Shanafelt, T.d., Cutrona, G., Molica, S., Tripepi, G., Alvarez, I., Mauro, F.R., Di Renzo, N., Di Raimondo, F., Vincelli, I., Todoerti, K., Matis, S., Musolino, C., Fabris, S., Vigna, E., Levato, L., Zupo, S., Angrilli, F., Consoli, U., Festini, G., et al.. - In: LEUKEMIA. - ISSN 0887-6924. - 30:6(2016), pp. 1440-1443. [10.1038/leu.2015.333]
A progression-risk score to predict treatment-free survival for early stage chronic lymphocytic leukemia patients
FEDERICO, Massimo;
2016
Abstract
Several phenotypic, molecular and chromosomal markers of chronic lymphocytic leukemia (CLL) cells have been identified that are significantly associated with patient prognosis.1, 2, 3, 4, 5, 6 However, these markers used singularly are inaccurate predictors of outcome for individual patients. Recent efforts have focused on combining markers to predict either treatment-free survival (TFS)4, 7, 8 or overall survival (OS),9, 10, 11 however, further effort is worthwhile to determine how to combine prognostic parameters, optimize risk stratification, simplify calculations and/or identify new prognostic variables.
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