The ability of a Ce-containing bioactive glasses to inhibit oxidative stress in terms of reduction of H2O2, by mimicking the catalase enzyme activity is demonstrated for the first time. The antioxidant properties of bioactive glasses containing CeO2 have been evaluated by following the degradation of hydrogen peroxide with time after immersion in H2O2 aqueous solutions with different concentration. XPS, UV-Vis and magnetic measurements allowed us to determine the Ce3+/Ce4+ ratio (bulk and surface) and to correlate it with the ability of the samples to show catalase mimetic activity. We have found that the bioactive glass (23.2Na2O-25.7CaO-43.4SiO2-2.4P2O5-5.3CeO2) immersed in 0.1M H2O2 aqueous solution is able to degrade 90% of it in one week.

CATALYTIC BIOACTIVE GLASSES: CATALASE MIMETIC ACTIVITY, AN EXAMPLE / Malavasi, Gianluca; Nicolini, Valentina; Gambuzzi, Elisa; Menabue, Ledi; Lusvardi, Gigliola; Pedone, Alfonso; Benedetti, Francesco; Luches, Paola; D'Addato, Sergio; Valeri, Sergio. - In: JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS. - ISSN 2280-8000. - ELETTRONICO. - 14:1(2016), pp. 0-0. [10.5301/jabfm.5000272]

CATALYTIC BIOACTIVE GLASSES: CATALASE MIMETIC ACTIVITY, AN EXAMPLE

MALAVASI, Gianluca;NICOLINI, VALENTINA;GAMBUZZI, ELISA;MENABUE, Ledi;LUSVARDI, Gigliola;PEDONE, Alfonso;BENEDETTI, FRANCESCO;LUCHES, Paola;D'ADDATO, Sergio;VALERI, Sergio
2016

Abstract

The ability of a Ce-containing bioactive glasses to inhibit oxidative stress in terms of reduction of H2O2, by mimicking the catalase enzyme activity is demonstrated for the first time. The antioxidant properties of bioactive glasses containing CeO2 have been evaluated by following the degradation of hydrogen peroxide with time after immersion in H2O2 aqueous solutions with different concentration. XPS, UV-Vis and magnetic measurements allowed us to determine the Ce3+/Ce4+ ratio (bulk and surface) and to correlate it with the ability of the samples to show catalase mimetic activity. We have found that the bioactive glass (23.2Na2O-25.7CaO-43.4SiO2-2.4P2O5-5.3CeO2) immersed in 0.1M H2O2 aqueous solution is able to degrade 90% of it in one week.
2016
14
1
0
0
CATALYTIC BIOACTIVE GLASSES: CATALASE MIMETIC ACTIVITY, AN EXAMPLE / Malavasi, Gianluca; Nicolini, Valentina; Gambuzzi, Elisa; Menabue, Ledi; Lusvardi, Gigliola; Pedone, Alfonso; Benedetti, Francesco; Luches, Paola; D'Addato, Sergio; Valeri, Sergio. - In: JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS. - ISSN 2280-8000. - ELETTRONICO. - 14:1(2016), pp. 0-0. [10.5301/jabfm.5000272]
Malavasi, Gianluca; Nicolini, Valentina; Gambuzzi, Elisa; Menabue, Ledi; Lusvardi, Gigliola; Pedone, Alfonso; Benedetti, Francesco; Luches, Paola; D'A...espandi
File in questo prodotto:
File Dimensione Formato  
JABFM-favignana2015.pdf

Accesso riservato

Tipologia: Versione pubblicata dall'editore
Dimensione 5.87 MB
Formato Adobe PDF
5.87 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1102738
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact