In patients with cluster headache (CH) testosterone plasma levels have been consinstently reported to be lower than in normal males. Thus, we studied LH pulsatile secretory pattern in a group of 29 males suffering from CH. Ten of them were studied longitudinally, while 19 were studied cross-sectionally only during active (n=9) or attack free (n=10) phases. Nine healthy, age-matched males were studied as reference group. All subjects underwent a pulsatility study of 6 hours, sampling every 15 minutes. CH patients resulted to have a lower LH pulsatile release both during active (3.6+/-0.9 peaks/6h, p<0.0001) and attack free (4.1+/-0.9 peaks/6h, p<0.004) phases than normal males (5.2+/-0.6 peaks/6h). When longitudinally studied, CH patients (n=10) showed lower LH secretory episodes during the active than during the attack free phase (3.3+/-0.9 and 4.1+/-0.7 peaks/6h, p<0.05). Testosterone plasma levels did not differ between active and free phases (4.3+/-1 and 4.7+/-0.8 ng/ml, respectively), while, in patients they were significantly lower than in controls (6.8+/-0.9 ng/ml, p<0.01)). These data demonstrate an impaired function of the hypothalamo-pituitary axis possibly due to an overactivity of the opioid neuromodulation.
|Anno di pubblicazione:||1993|
|Titolo:||DERANGEMENT OF LH EPISODIC SECRETION IN CLUSTER HEADACHE SUFFERERS|
|Autori:||GENAZZANI AD; MICIELI G; MARTIGNONI E; FACCHINETTI F; RODBARD D; NAPPI G|
|Appare nelle tipologie:||Articolo su rivista|
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