In patients with cluster headache (CH) testosterone plasma levels have been consinstently reported to be lower than in normal males. Thus, we studied LH pulsatile secretory pattern in a group of 29 males suffering from CH. Ten of them were studied longitudinally, while 19 were studied cross-sectionally only during active (n=9) or attack free (n=10) phases. Nine healthy, age-matched males were studied as reference group. All subjects underwent a pulsatility study of 6 hours, sampling every 15 minutes. CH patients resulted to have a lower LH pulsatile release both during active (3.6+/-0.9 peaks/6h, p<0.0001) and attack free (4.1+/-0.9 peaks/6h, p<0.004) phases than normal males (5.2+/-0.6 peaks/6h). When longitudinally studied, CH patients (n=10) showed lower LH secretory episodes during the active than during the attack free phase (3.3+/-0.9 and 4.1+/-0.7 peaks/6h, p<0.05). Testosterone plasma levels did not differ between active and free phases (4.3+/-1 and 4.7+/-0.8 ng/ml, respectively), while, in patients they were significantly lower than in controls (6.8+/-0.9 ng/ml, p<0.01)). These data demonstrate an impaired function of the hypothalamo-pituitary axis possibly due to an overactivity of the opioid neuromodulation.

DERANGEMENT OF LH EPISODIC SECRETION IN CLUSTER HEADACHE SUFFERERS / Genazzani, Alessandro; Micieli, G; Martignoni, E; Facchinetti, Fabio; Rodbard, D; Nappi, G.. - In: NEUROENDOCRINOLOGY LETTERS. - ISSN 0172-780X. - STAMPA. - 15:(1993), pp. 443-449.

DERANGEMENT OF LH EPISODIC SECRETION IN CLUSTER HEADACHE SUFFERERS

GENAZZANI, Alessandro;FACCHINETTI, Fabio;
1993-01-01

Abstract

In patients with cluster headache (CH) testosterone plasma levels have been consinstently reported to be lower than in normal males. Thus, we studied LH pulsatile secretory pattern in a group of 29 males suffering from CH. Ten of them were studied longitudinally, while 19 were studied cross-sectionally only during active (n=9) or attack free (n=10) phases. Nine healthy, age-matched males were studied as reference group. All subjects underwent a pulsatility study of 6 hours, sampling every 15 minutes. CH patients resulted to have a lower LH pulsatile release both during active (3.6+/-0.9 peaks/6h, p<0.0001) and attack free (4.1+/-0.9 peaks/6h, p<0.004) phases than normal males (5.2+/-0.6 peaks/6h). When longitudinally studied, CH patients (n=10) showed lower LH secretory episodes during the active than during the attack free phase (3.3+/-0.9 and 4.1+/-0.7 peaks/6h, p<0.05). Testosterone plasma levels did not differ between active and free phases (4.3+/-1 and 4.7+/-0.8 ng/ml, respectively), while, in patients they were significantly lower than in controls (6.8+/-0.9 ng/ml, p<0.01)). These data demonstrate an impaired function of the hypothalamo-pituitary axis possibly due to an overactivity of the opioid neuromodulation.
15
443
449
DERANGEMENT OF LH EPISODIC SECRETION IN CLUSTER HEADACHE SUFFERERS / Genazzani, Alessandro; Micieli, G; Martignoni, E; Facchinetti, Fabio; Rodbard, D; Nappi, G.. - In: NEUROENDOCRINOLOGY LETTERS. - ISSN 0172-780X. - STAMPA. - 15:(1993), pp. 443-449.
Genazzani, Alessandro; Micieli, G; Martignoni, E; Facchinetti, Fabio; Rodbard, D; Nappi, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/10955
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