Among human immunodeficiency virus (HIV)-infected persons, those who react against purified protein derivative (PPD) have higher risk of tuberculosis. Since PPD testing has limited predictive power in HIV-positive populations, new markers of antituberculous immunity were sought by analyzing antibodies to Mycobacterium tuberculosis antigens (PPD and its fraction A60) in 102 HIV-positive subjects, some PPD-positive and some PPD-negative, and in 23 HIV-positive tuberculosis patients. ELISA and Western blotting were used. Forty HIV-negative healthy subjects and 40 HIV-negative tuberculosis patients were evaluated as controls. While all those HIV-negative and PPD-positive had IgG antibodies recognizing the 38-, 28-, and 19-kDa M. tuberculosis antigens, only 26% of those HIV-positive and PPD-positive (all with <400 CD4+ cells/mm3) and none of the HIV-positive tuberculosis patients recognized them, indicating that the lack of IgG against those antigens, in the presence of a specific IgM response, is a marker of immunodeficiency.

EARLY ABNORMALITIES OF THE ANTIBODY-RESPONSE AGAINST MYCOBACTERIUM-TUBERCULOSIS IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION / Saltini, C; Amicosante, M; Girardi, E; Antonucci, G; Ippolito, G; Ameglio, F; Monno, L; Congedo, P; Angarano, G; Babudieri, S; Guaraldi, Giovanni; Visco, G; Piccolella, E; Paone, G; Pallotta, G; Bisetti, A.. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - STAMPA. - 168:(1993), pp. 1409-1414.

EARLY ABNORMALITIES OF THE ANTIBODY-RESPONSE AGAINST MYCOBACTERIUM-TUBERCULOSIS IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION

GUARALDI, Giovanni;
1993-01-01

Abstract

Among human immunodeficiency virus (HIV)-infected persons, those who react against purified protein derivative (PPD) have higher risk of tuberculosis. Since PPD testing has limited predictive power in HIV-positive populations, new markers of antituberculous immunity were sought by analyzing antibodies to Mycobacterium tuberculosis antigens (PPD and its fraction A60) in 102 HIV-positive subjects, some PPD-positive and some PPD-negative, and in 23 HIV-positive tuberculosis patients. ELISA and Western blotting were used. Forty HIV-negative healthy subjects and 40 HIV-negative tuberculosis patients were evaluated as controls. While all those HIV-negative and PPD-positive had IgG antibodies recognizing the 38-, 28-, and 19-kDa M. tuberculosis antigens, only 26% of those HIV-positive and PPD-positive (all with <400 CD4+ cells/mm3) and none of the HIV-positive tuberculosis patients recognized them, indicating that the lack of IgG against those antigens, in the presence of a specific IgM response, is a marker of immunodeficiency.
168
1409
1414
EARLY ABNORMALITIES OF THE ANTIBODY-RESPONSE AGAINST MYCOBACTERIUM-TUBERCULOSIS IN HUMAN-IMMUNODEFICIENCY-VIRUS INFECTION / Saltini, C; Amicosante, M; Girardi, E; Antonucci, G; Ippolito, G; Ameglio, F; Monno, L; Congedo, P; Angarano, G; Babudieri, S; Guaraldi, Giovanni; Visco, G; Piccolella, E; Paone, G; Pallotta, G; Bisetti, A.. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - STAMPA. - 168:(1993), pp. 1409-1414.
Saltini, C; Amicosante, M; Girardi, E; Antonucci, G; Ippolito, G; Ameglio, F; Monno, L; Congedo, P; Angarano, G; Babudieri, S; Guaraldi, Giovanni; Visco, G; Piccolella, E; Paone, G; Pallotta, G; Bisetti, A.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/10884
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 14
  • ???jsp.display-item.citation.isi??? 16
social impact