Chronic/recurrent behaviour may be encountered in some distinct atypical or malignant lymphoproliferations, while recurrences are not generally observed in reactive/benign lymphadenopathies. We retrospectively anal- ysed a consecutive series of 486 human immunodeﬁciency virus-negative adults, who underwent lymphadenectomy. Neoplastic and benign/reactive histopathological pictures were documented in 299 (61 5%) and 187 (38 5%) cases, respectively. Of note, seven of the 111 (6 3%) patients with benign lymphadenopathy without well-deﬁned aetiology, showed chronic/ recurrent behaviour, without constitutional symptoms. Enlarged lymph nodes were round in shape and hypoechoic, mimicking lymphoma. Reac- tive follicular hyperplasia and paracortical expansion were observed. Human herpesvirus (HHV)-6B positive staining in follicular dendritic cells (FDCs) was documented in all seven patients. Serological, molecular and immunological examinations suggested HHV-6B reactivation. Among the remaining 104 cases with reactive lymphoid hyperplasia in the absence of well-known aetiology and without recurrences, positivity for HHV-6B on FDCs was found in three cases, whereas in seven further patients, a scanty positivity was documented in rare, scattered cells in inter-follicular regions. Immunohistochemistry for HHV-6A and HHV-6B was invariably negative on 134 lymph nodes, with either benign pictures with known aetiology or malignant lymphoproliferative disorders, tested as further controls. Future studies are warranted to investigate a potential association between HHV- 6B reactivation and chronic/recurrent benign lymphadenopathy.
|Data di pubblicazione:||2016|
|Titolo:||Chronic and recurrent benign lymphadenopathy without constitutional symptoms associated with human herpesvirus-6B reactivation|
|Autori:||Fabio Forghieri; Mario Luppi; Patrizia Barozzi; Giovanni Riva; Monica Morselli; Sara Bigliardi; Chiara Quadrelli; Daniela Vallerini; Monica Maccaferri; Valeria Coluccio; Ambra Paolini; Elisabetta Colaci; Goretta Bonacorsi; Antonino Maiorana; Sara Tagliazucchi; Fabio Rumpianesi; Francesco Mattioli; Livio Presutti; Roberta Gelmini; Claudio Cermelli; Giulio Rossi; Patrizia Comoli; Roberto Marasca; Franco Narni; Potenza Leonardo|
|Digital Object Identifier (DOI):||10.1111/bjh.13871|
|Appare nelle tipologie:||Articolo su rivista|
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