The correlation between cyclin D1 overexpression and the clinical outcome of head and neck cancer is not defined. The aim of this meta-analysis was to evaluate the prognostic value of cyclin D1 in patients with head and neck cancer. A search thorough Ovid MEDLINE was performed to enroll all eligible articles. Twenty-two studies comprising a total of 1,929 patients with different head and neck cancers were included. Cyclin D1 overexpression was significantly associated with lymph node metastasis [OR 2.25; 95 % confidence interval (CI) 1.76-2.87] and worse disease-free survival (OR 3.06; 95 % CI 2.42-3.87]. Subgroup analysis revealed that cyclin D1 overexpression correlated significantly with nodal metastasis for laryngeal cancer (OR 2.26; 95 % CI 1.61-3.16) and was a significant poor predictor for nasopharyngeal cancer (OR 4.44; 95 % CI 1.89-10.42). Our meta-analysis suggests that cyclin D1 overexpression could represent an important prognostic indicator for patients with head and neck cancer.

The prognostic value of cyclin D1 expression in head and neck squamous cell carcinoma / Gioacchini, Federico Maria; Alicandri Ciufelli, Matteo; Kaleci, Shaniko; Magliulo, Giuseppe; Presutti, Livio; Re, Massimo. - In: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY AND HEAD & NECK. - ISSN 1434-4726. - (2016), pp. 1-10. [10.1007/s00405-014-3426-3]

The prognostic value of cyclin D1 expression in head and neck squamous cell carcinoma

GIOACCHINI, FEDERICO MARIA;ALICANDRI CIUFELLI, Matteo;KALECI, SHANIKO;PRESUTTI, Livio;
2016

Abstract

The correlation between cyclin D1 overexpression and the clinical outcome of head and neck cancer is not defined. The aim of this meta-analysis was to evaluate the prognostic value of cyclin D1 in patients with head and neck cancer. A search thorough Ovid MEDLINE was performed to enroll all eligible articles. Twenty-two studies comprising a total of 1,929 patients with different head and neck cancers were included. Cyclin D1 overexpression was significantly associated with lymph node metastasis [OR 2.25; 95 % confidence interval (CI) 1.76-2.87] and worse disease-free survival (OR 3.06; 95 % CI 2.42-3.87]. Subgroup analysis revealed that cyclin D1 overexpression correlated significantly with nodal metastasis for laryngeal cancer (OR 2.26; 95 % CI 1.61-3.16) and was a significant poor predictor for nasopharyngeal cancer (OR 4.44; 95 % CI 1.89-10.42). Our meta-analysis suggests that cyclin D1 overexpression could represent an important prognostic indicator for patients with head and neck cancer.
12-dic-2014
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The prognostic value of cyclin D1 expression in head and neck squamous cell carcinoma / Gioacchini, Federico Maria; Alicandri Ciufelli, Matteo; Kaleci, Shaniko; Magliulo, Giuseppe; Presutti, Livio; Re, Massimo. - In: EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY AND HEAD & NECK. - ISSN 1434-4726. - (2016), pp. 1-10. [10.1007/s00405-014-3426-3]
Gioacchini, FEDERICO MARIA; ALICANDRI CIUFELLI, Matteo; Kaleci, Shaniko; Magliulo, Giuseppe; Presutti, Livio; Re, Massimo
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1083042
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