The phenotypic characteristics of peripheral blood lymphocytes were investigated in 22 patients suffering from active polymyalgia rheumatica/giant cell arteritis (PMR/GCA) prior to steroid treatment. We observed a significant reduction in the absolute number and the relative percentage of CD4-, CD8+ and CD3+, CD16+ and/or CD56+ cells compared to controls. Fifteen patients were investigated prospectively over a 6-month period of prednisone therapy. At the end of the study CD4-CD8+ cells had increased significantly compared to baselines, CD3+ CD16+ and/or CD56+ cells remained significantly lower when compared to controls. We did not observe any abnormalities in the absolute number and percentage of HLA-DR+ T lymphocytes, CD5+ B cells and NK cell phenotypes before or during steroid treatment. Our study confirms that there was significant increase in the absolute number of CD8+ T cells during steroid treatment in the PMR/GCA patients, but indicates the persistence of an immunological alteration despite the control of disease manifestations.

Lymphocyte subpopulations analysis in peripheral blood in polymyalgia rheumatica/giant cell arteritis / Macchioni, P; Boiardi, L; Salvarani, Carlo; Rossi, F; Casadei Maldini, M; Mancini, R; Beltrandi, E; Portioli, I.. - In: BRITISH JOURNAL OF RHEUMATOLOGY. - ISSN 0263-7103. - 32:(1993), pp. 666-670.

Lymphocyte subpopulations analysis in peripheral blood in polymyalgia rheumatica/giant cell arteritis

SALVARANI, CARLO;
1993

Abstract

The phenotypic characteristics of peripheral blood lymphocytes were investigated in 22 patients suffering from active polymyalgia rheumatica/giant cell arteritis (PMR/GCA) prior to steroid treatment. We observed a significant reduction in the absolute number and the relative percentage of CD4-, CD8+ and CD3+, CD16+ and/or CD56+ cells compared to controls. Fifteen patients were investigated prospectively over a 6-month period of prednisone therapy. At the end of the study CD4-CD8+ cells had increased significantly compared to baselines, CD3+ CD16+ and/or CD56+ cells remained significantly lower when compared to controls. We did not observe any abnormalities in the absolute number and percentage of HLA-DR+ T lymphocytes, CD5+ B cells and NK cell phenotypes before or during steroid treatment. Our study confirms that there was significant increase in the absolute number of CD8+ T cells during steroid treatment in the PMR/GCA patients, but indicates the persistence of an immunological alteration despite the control of disease manifestations.
32
666
670
Lymphocyte subpopulations analysis in peripheral blood in polymyalgia rheumatica/giant cell arteritis / Macchioni, P; Boiardi, L; Salvarani, Carlo; Rossi, F; Casadei Maldini, M; Mancini, R; Beltrandi, E; Portioli, I.. - In: BRITISH JOURNAL OF RHEUMATOLOGY. - ISSN 0263-7103. - 32:(1993), pp. 666-670.
Macchioni, P; Boiardi, L; Salvarani, Carlo; Rossi, F; Casadei Maldini, M; Mancini, R; Beltrandi, E; Portioli, I.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1082991
Citazioni
  • ???jsp.display-item.citation.pmc??? 7
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 29
social impact