A case of chronic neutrophilic leukemia (CNL), a rare myeloproliferative syndrome associated with monoclonal gammopathy of uncertain significance (MGUS-Type IgGk), is reported. Karyotypic study, carried out on bone marrow, excluded Philadelphia-pos. chronic myeloid leukemia (CML) and showed Y loss (45 XO). Only a few cases of CNL with paraproteinemia have been reported, but no case of associated karyotypic abnormalities and paraproteinemia has so far been described.
Chronic neutrophilic leukemia (CNL) with karyotypic abnormalities associated with plasma cell dyscrasia: a case report / Masini, L; Salvarani, Carlo; Macchioni, P; Baldi, G; Rossi, F; Croci, G; Prandi, S; Davoli, C; Portioli, I; Gobbi, F.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - 77:(1992), pp. 277-279.