Retroperitoneal fibrosis encompasses a range of diseases characterised by the presence of a fibro-inflammatory tissue, which usually surrounds the abdominal aorta and the iliac arteries and extends into the retroperitoneum to envelop neighbouring structures--eg, ureters. Retroperitoneal fibrosis is generally idiopathic, but can also be secondary to the use of certain drugs, malignant diseases, infections, and surgery. Idiopathic disease was thought to result from a local inflammatory reaction to antigens in the atherosclerotic plaques of the abdominal aorta, but clinicolaboratory findings--namely, the presence of constitutional symptoms and the high concentrations of acute-phase reactants--and the frequent association of the disease with autoimmune diseases that involve other organs suggest that it might be a manifestation of a systemic autoimmune or inflammatory disease. Steroids are normally used to treat idiopathic retroperitoneal fibrosis, although other options--eg, immunosuppressants, tamoxifen--are available. The outlook is usually good, but, if not appropriately diagnosed or treated, the disease can cause severe complications, such as end-stage renal failure. Here, we review the different aspects of retroperitoneal fibrosis, focusing on idiopathic retroperitoneal fibrosis and on the differential diagnosis associated with the secondary forms.
Retroperitoneal fibrosis / Vaglio, Augusto; Salvarani, Carlo; Buzio, Carlo. - In: THE LANCET. - ISSN 0140-6736. - 367(2006), pp. 241-251. [10.1016/S0140-6736(06)68035-5]
Data di pubblicazione: | 2006 | |
Titolo: | Retroperitoneal fibrosis | |
Autore/i: | Vaglio, Augusto; Salvarani, Carlo; Buzio, Carlo | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0140-6736(06)68035-5 | |
Rivista: | ||
Volume: | 367 | |
Pagina iniziale: | 241 | |
Pagina finale: | 251 | |
Codice identificativo ISI: | WOS:000234810600030 | |
Codice identificativo Scopus: | 2-s2.0-30844451801 | |
Codice identificativo Pubmed: | 16427494 | |
Citazione: | Retroperitoneal fibrosis / Vaglio, Augusto; Salvarani, Carlo; Buzio, Carlo. - In: THE LANCET. - ISSN 0140-6736. - 367(2006), pp. 241-251. [10.1016/S0140-6736(06)68035-5] | |
Tipologia | Articolo su rivista |
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