To assess the role of -174 G/C promoter polymorphism of interleukin 6 (IL-6) in the susceptibility to polymyalgia rheumatica (PMR). We also investigated whether this polymorphism modulates the circulating level of IL-6 and the risk of relapse/recurrence in a series of patients with PMR followed up prospectively.
Relationship between interleukin 6 promoter polymorphism at position -174, IL-6 serum levels, and the risk of relapse/recurrence in polymyalgia rheumatica / Boiardi, Luigi; Casali, Bruno; Farnetti, Enrico; Pipitone, Nicolò; Nicoli, Davide; Cantini, Fabrizio; Macchioni, Pierluigi; Bajocchi, Gianluigi; Catanoso, Maria Grazia; Pulsatelli, Lia; Consonni, Dario; Salvarani, Carlo. - In: THE JOURNAL OF RHEUMATOLOGY. - ISSN 0315-162X. - 33:(2006), pp. 703-708.
Relationship between interleukin 6 promoter polymorphism at position -174, IL-6 serum levels, and the risk of relapse/recurrence in polymyalgia rheumatica
SALVARANI, CARLO
2006
Abstract
To assess the role of -174 G/C promoter polymorphism of interleukin 6 (IL-6) in the susceptibility to polymyalgia rheumatica (PMR). We also investigated whether this polymorphism modulates the circulating level of IL-6 and the risk of relapse/recurrence in a series of patients with PMR followed up prospectively.
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