The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on (18)F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma.
Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients / Meignan, M; Sasanelli, M; Casasnovas, Ro; Luminari, Stefano; Fioroni, F; Coriani, C; Masset, H; Itti, E; Gobbi, Pg; Merli, F; Versari, A.. - In: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. - ISSN 1619-7070. - 41:(2014), pp. 1113-22-1122. [10.1007/s00259-014-2705-y]
Metabolic tumour volumes measured at staging in lymphoma: methodological evaluation on phantom experiments and patients
LUMINARI, Stefano;
2014
Abstract
The presence of a bulky tumour at staging on CT is an independent prognostic factor in malignant lymphomas. However, its prognostic value is limited in diffuse disease. Total metabolic tumour volume (TMTV) determined on (18)F-FDG PET/CT could give a better evaluation of the total tumour burden and may help patient stratification. Different methods of TMTV measurement established in phantoms simulating lymphoma tumours were investigated and validated in 40 patients with Hodgkin lymphoma and diffuse large B-cell lymphoma.
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