Splenic marginal zone lymphoma (SMZL) is an indolent B-cell tumor involving the spleen, and is characterized by recurrent deletion of chromosome 7q and biased usage of the immunoglobulin heavy variable (IGHV) allele 1-2*04.1 Genomic studies have partially unraveled the typical SMZL-coding genome, which is characterized by lesions affecting genes involved in the physiological homeostasis of marginal zone (MZ) B cells, including mutations of NOTCH2.2, 3, 4, 5 However, the full spectrum of lesions that contribute to the malignant transformation of SMZL remains unknown.
The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma / Piva, R., Deaglio, S., Famà, R., Buonincontri, R., Scarfò, I., Bruscaggin, A., Mereu, E., Serra, S., Spina, V., Brusa, D., Garaffo, G., Monti, S., Dal Bo, M., Marasca, R., Arcaini, L., Neri, A., Gattei, V., Paulli, M., Tiacci, E., Bertoni, F., et al.. - In: LEUKEMIA. - ISSN 0887-6924. - STAMPA. - 29:2(2015), pp. 503-507. [10.1038/leu.2014.294]
The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma
MARASCA, Roberto;
2015
Abstract
Splenic marginal zone lymphoma (SMZL) is an indolent B-cell tumor involving the spleen, and is characterized by recurrent deletion of chromosome 7q and biased usage of the immunoglobulin heavy variable (IGHV) allele 1-2*04.1 Genomic studies have partially unraveled the typical SMZL-coding genome, which is characterized by lesions affecting genes involved in the physiological homeostasis of marginal zone (MZ) B cells, including mutations of NOTCH2.2, 3, 4, 5 However, the full spectrum of lesions that contribute to the malignant transformation of SMZL remains unknown.
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