Splenic marginal zone lymphoma (SMZL) is an indolent B-cell tumor involving the spleen, and is characterized by recurrent deletion of chromosome 7q and biased usage of the immunoglobulin heavy variable (IGHV) allele 1-2*04.1 Genomic studies have partially unraveled the typical SMZL-coding genome, which is characterized by lesions affecting genes involved in the physiological homeostasis of marginal zone (MZ) B cells, including mutations of NOTCH2.2, 3, 4, 5 However, the full spectrum of lesions that contribute to the malignant transformation of SMZL remains unknown.
The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma / Piva, R; Deaglio, S; Famà, R; Buonincontri, R; Scarfò, I; Bruscaggin, A; Mereu, E; Serra, S; Spina, V; Brusa, D; Garaffo, G; Monti, S; Dal Bo, M; Marasca, Roberto; Arcaini, L; Neri, A; Gattei, V; Paulli, M; Tiacci, E; Bertoni, F; Pileri, Sa; Foà, R; Inghirami, G; Gaidano, G; Rossi, D.. - In: LEUKEMIA. - ISSN 0887-6924. - STAMPA. - 29:2(2015), pp. 503-507. [10.1038/leu.2014.294]
The Krüppel-like factor 2 transcription factor gene is recurrently mutated in splenic marginal zone lymphoma
MARASCA, Roberto;
2015
Abstract
Splenic marginal zone lymphoma (SMZL) is an indolent B-cell tumor involving the spleen, and is characterized by recurrent deletion of chromosome 7q and biased usage of the immunoglobulin heavy variable (IGHV) allele 1-2*04.1 Genomic studies have partially unraveled the typical SMZL-coding genome, which is characterized by lesions affecting genes involved in the physiological homeostasis of marginal zone (MZ) B cells, including mutations of NOTCH2.2, 3, 4, 5 However, the full spectrum of lesions that contribute to the malignant transformation of SMZL remains unknown.File | Dimensione | Formato | |
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