Abstract BACKGROUND: Relatively few data are available on long-term echocardiographic optimization of atrioventricular (AV) and interventricular (VV) delay programming in cardiac resynchronization therapy (CRT). We assessed variations in optimized AV and VV delays during long-term follow-up. METHODS: Thirty-seven consecutive heart failure patients received Doppler echocardiographic optimization of AV and VV delay within 48 hours from CRT device implantation, at 6 months and at 12 months (the last for the first enrolled 14 patients). RESULTS: After implantation, median optimized AV delay was 100 ms (range, 45 ms); VV optimization led to simultaneous biventricular activation in 4 patients, left ventricular preactivation in 17 patients and right ventricular preactivation in 16 patients. At 12 months median AV delay decreased to 85 ms (23 ms) (P < 0.05 vs. baseline). With respect to previous assessment, VV delay variations > or =40 ms were observed in 41% of the patients at 6 months and in 57% of the tested patients at 12 months. A nonconcordance (by Kappa test) of optimized VV delays was found between each new assessment and the previous one. VV delay optimization was associated with significant (P < 0.001) increases in aortic velocity time integral both at baseline and during follow-up. CONCLUSIONS: Echocardiographic optimization of AV and VV delay is associated with broad intraindividual variability during follow-up. A new assessment of optimized VV delays during long-term follow-up reveals a nonconcordance with previous values and provides increases in forward stroke volume.

Cardiac resynchronization therapy: variations in echo-guided optimized atrioventricular and interventricular delays during follow-up / Valzania, C; Biffi, M; Martignani, C; Diemberger, I; Bertini, M; Ziacchi, M; Bacchi, L; Rocchi, G; Rapezzi, C; Branzi, A; Boriani, Giuseppe. - In: ECHOCARDIOGRAPHY. - ISSN 0742-2822. - 24:9(2007), pp. 933-939. [10.1111/j.1540-8175.2007.00491.x ]

Cardiac resynchronization therapy: variations in echo-guided optimized atrioventricular and interventricular delays during follow-up.

BORIANI, Giuseppe
2007

Abstract

Abstract BACKGROUND: Relatively few data are available on long-term echocardiographic optimization of atrioventricular (AV) and interventricular (VV) delay programming in cardiac resynchronization therapy (CRT). We assessed variations in optimized AV and VV delays during long-term follow-up. METHODS: Thirty-seven consecutive heart failure patients received Doppler echocardiographic optimization of AV and VV delay within 48 hours from CRT device implantation, at 6 months and at 12 months (the last for the first enrolled 14 patients). RESULTS: After implantation, median optimized AV delay was 100 ms (range, 45 ms); VV optimization led to simultaneous biventricular activation in 4 patients, left ventricular preactivation in 17 patients and right ventricular preactivation in 16 patients. At 12 months median AV delay decreased to 85 ms (23 ms) (P < 0.05 vs. baseline). With respect to previous assessment, VV delay variations > or =40 ms were observed in 41% of the patients at 6 months and in 57% of the tested patients at 12 months. A nonconcordance (by Kappa test) of optimized VV delays was found between each new assessment and the previous one. VV delay optimization was associated with significant (P < 0.001) increases in aortic velocity time integral both at baseline and during follow-up. CONCLUSIONS: Echocardiographic optimization of AV and VV delay is associated with broad intraindividual variability during follow-up. A new assessment of optimized VV delays during long-term follow-up reveals a nonconcordance with previous values and provides increases in forward stroke volume.
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Cardiac resynchronization therapy: variations in echo-guided optimized atrioventricular and interventricular delays during follow-up / Valzania, C; Biffi, M; Martignani, C; Diemberger, I; Bertini, M; Ziacchi, M; Bacchi, L; Rocchi, G; Rapezzi, C; Branzi, A; Boriani, Giuseppe. - In: ECHOCARDIOGRAPHY. - ISSN 0742-2822. - 24:9(2007), pp. 933-939. [10.1111/j.1540-8175.2007.00491.x ]
Valzania, C; Biffi, M; Martignani, C; Diemberger, I; Bertini, M; Ziacchi, M; Bacchi, L; Rocchi, G; Rapezzi, C; Branzi, A; Boriani, Giuseppe
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1080496
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