Propafenone and carvedilol share a common hepatic metabolism involving the oxidative pathway (CYP2D6). Therefore, oral loading with propafenone (as "pill-in-the-pocket" treatment of recent-onset atrial fibrillation) in a patient on concurrent carvedilol treatment may lead to a pharmacokinetic interaction, with high plasma levels of propafenone and potential drug-related adverse effects. In clinical practice, in order to improve the safety of "pill-in-the-pocket" treatment, use of propafenone loading should, in our view, be discouraged in patients on concurrent treatment with carvedilol.
Atrial fibrillation: Adverse effects of "pill-in-the-pocket" treatment and propafenone-carvedilol interaction / Boriani, Giuseppe; Biffi, M; Diemberger, I; Domenichini, G; Marziali, A; Martignani, C.. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 140:2(2010), pp. 242-243.
Data di pubblicazione: | 2010 |
Titolo: | Atrial fibrillation: Adverse effects of "pill-in-the-pocket" treatment and propafenone-carvedilol interaction. |
Autore/i: | Boriani, Giuseppe; Biffi, M; Diemberger, I; Domenichini, G; Marziali, A; Martignani, C. |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.ijcard.2008.11.028 |
Rivista: | |
Volume: | 140 |
Fascicolo: | 2 |
Pagina iniziale: | 242 |
Pagina finale: | 243 |
Codice identificativo ISI: | WOS:000276407100017 |
Codice identificativo Scopus: | 2-s2.0-77950340923 |
Codice identificativo Pubmed: | 19062111 |
Citazione: | Atrial fibrillation: Adverse effects of "pill-in-the-pocket" treatment and propafenone-carvedilol interaction / Boriani, Giuseppe; Biffi, M; Diemberger, I; Domenichini, G; Marziali, A; Martignani, C.. - In: INTERNATIONAL JOURNAL OF CARDIOLOGY. - ISSN 0167-5273. - 140:2(2010), pp. 242-243. |
Tipologia | Articolo su rivista |
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