EnglishObjective. The aim of this study was to compare baseline variables, treatment and outcomes in patients with large-vessel GCA (LV-GCA), primarily of the upper extremities, with those with cranial disease (C-GCA). Methods. All patients > 50 years of age with radiographic evidence of subclavian LV-GCA diagnosed between 1 January 1999 and 31 December 2008 were identified and compared with those with biopsypositive C-GCA diagnosed in the same period. Results. The study included 120 LV-GCA patients and 212 C-GCA patients. Compared with C-GCA, patients with LV-GCA were younger [68.2 years (S.D. 7.5) vs 75.7 (7.4), P < 0.001] and had longer duration of symptoms at GCA diagnosis (median 3.5 vs 2.2 months, P < 0.001). A history of PMR was more common in LV-GCA patients (26% vs 15%, P = 0.012), but a smaller proportion had cranial symptoms (41% vs 83%, P < 0.001) and vision loss (4% vs 11%, P = 0.035). ACR classification criteria for GCA were satisfied in 39% of LV-GCA patients and 95% of C-GCA patients (P < 0.001). Compared with C-GCA, patients with LV-GCA had more relapses (4.9 vs 3.0/10 person-years, P < 0.001), higher cumulative corticosteroid (CS) doses at 1 year [11.4 g (S.D. 5.9) vs 9.1 (S.D. 3.7), P < 0.001] and required longer treatment (median 4.5 vs 2.2 years, P < 0.001). Conclusion. Although patients with LV-GCA had a lower rate of vision loss, they had a higher relapse rate and greater CS requirements. The ACR criteria for GCA are inadequate for the classification of patients with LV-GCA.
Large-vessel giant cell arteritis: a cohort study / Muratore, Francesco; Kermani, Tanaz A; Crowson, Cynthia S; Green, Abigail B; Salvarani, Carlo; Matteson, Eric L; Warrington, Kenneth J.. - In: RHEUMATOLOGY. - ISSN 1462-0332. - 54:3(2015), pp. 463-470.
| Data di pubblicazione: | 2015 | |
| Data di prima pubblicazione: | 5-set-2014 | |
| Titolo: | Large-vessel giant cell arteritis: a cohort study | |
| Autore/i: | Muratore, Francesco; Kermani, Tanaz A; Crowson, Cynthia S; Green, Abigail B; Salvarani, Carlo; Matteson, Eric L; Warrington, Kenneth J. | |
| Autore/i UNIMORE: | ||
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/rheumatology/keu329 | |
| Rivista: | ||
| Volume: | 54 | |
| Fascicolo: | 3 | |
| Pagina iniziale: | 463 | |
| Pagina finale: | 470 | |
| Codice identificativo ISI: | WOS:000352540900014 | |
| Codice identificativo Scopus: | 2-s2.0-84941619691 | |
| Codice identificativo Pubmed: | 25193809 | |
| Citazione: | Large-vessel giant cell arteritis: a cohort study / Muratore, Francesco; Kermani, Tanaz A; Crowson, Cynthia S; Green, Abigail B; Salvarani, Carlo; Matteson, Eric L; Warrington, Kenneth J.. - In: RHEUMATOLOGY. - ISSN 1462-0332. - 54:3(2015), pp. 463-470. | |
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