Angiogenesis and immunosuppression work hand-in-hand in the renal cell carcinoma (RCC) microenvironment. Tumor growth is associated with impaired antitumor immune response in RCC, which involves T cells, natural killer cells, dendritic cells (DCs) and macrophages. Vascular endothelial growth factor receptor (VEGFR), such as sorafenib, sunitinib, pazopanib and axitinib, and mammalian target of rapamycin (mTOR) inhibitors, such as temsirolimus and everolimus, do exert both antiangiogenic and immunomodulatory functions. Indeed, these agents affect neutrophil migration, as well as T lymphocyte-DC cross-talk, DC maturation and immune cell metabolism and reactivity. In this review, we overview the essential role of innate and adaptive immune response in RCC proliferation, invasion and metastasis and the relationship between tumor-associated immune cells and the response to targeted agents approved for the treatment of metastatic RCC.
Role of natural and adaptive immunity in renal cell carcinoma response to VEGFR-TKIs and mTOR inhibitor / Santoni, M; Berardi, R; Amantini, C; Burattini, L; Santini, D; Santoni, G; Cascinu, Stefano. - In: INTERNATIONAL JOURNAL OF CANCER. - ISSN 0020-7136. - Jun 15;134(12)(2014), pp. 2772-2777.
Data di pubblicazione: | 2014 |
Titolo: | Role of natural and adaptive immunity in renal cell carcinoma response to VEGFR-TKIs and mTOR inhibitor. |
Autore/i: | Santoni, M; Berardi, R; Amantini, C; Burattini, L; Santini, D; Santoni, G; Cascinu, Stefano |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/ijc.28503 |
Rivista: | |
Volume: | Jun 15;134(12) |
Pagina iniziale: | 2772 |
Pagina finale: | 2777 |
Codice identificativo ISI: | WOS:000333751000003 |
Codice identificativo Scopus: | 2-s2.0-84898011066 |
Codice identificativo Pubmed: | 24114790 |
Citazione: | Role of natural and adaptive immunity in renal cell carcinoma response to VEGFR-TKIs and mTOR inhibitor / Santoni, M; Berardi, R; Amantini, C; Burattini, L; Santini, D; Santoni, G; Cascinu, Stefano. - In: INTERNATIONAL JOURNAL OF CANCER. - ISSN 0020-7136. - Jun 15;134(12)(2014), pp. 2772-2777. |
Tipologia | Articolo su rivista |
File in questo prodotto:

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris