Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial.

Tak, Pp; Rigby, Wf; Rubbert Roth, A; Peterfy, Cg; Van Vollenhoven Rf,; Stohl, W; Hessey, E; Chen, A; Tyrrell, H; Shaw, Tm; Aelion J, Image I. N. V. E. S. T. I. G. A. T. O. R. S.; Afif, N; Ahmadi, F; Aires, F; Alanis, E; Alonso, Cs; Alten, Rh; Alvaro Gracia Jm,; Ashrafzadeh, A; Ballina, J; Bambara, Lm; Bao, C; Bell, M; Berney, S; Bessette, L; Birbara, C; Boling, E; Bourgeois, P; Braun, J; Briones, H; Brzezicki, J; Burgos Vargos, R; Burmester, G; Burnett, M; Busch, H; Cabello, E; Calvo, A; Cantagrel, A; Cantini, F; Zea, Ac; Carreño Perez, L; Chavez, J; Shim, Sc; Chindalore, V; Chiriac, R; Codding, C; Danda, D; Del Guidice, J; De Vita, S; Digiovanni, R; Dikranian, A; Eider, W; Fantini, F; Ferraccioli, G; Fietchner, J; Filipowicz Sosnowska, A; Finnanger, B; Fiocco, G; Fleck, M; Fleischmann, R; Fraser, A; Gaudin, P; Gauler, G; Gaylis, N; Gerlag, Dm; Godde, J; Gomez Reino Jj,; Gornisiewicz, M; Gough, W; Greenwald, M; Guerra, G; Hackshaw, K; Haentzschel, Hm; Hammond, T; Hazleman, Bl; Heilig, B; Herenius, Mm; Hilliquin, P; Holt, D; Huang, F; Huff, J; Huizinga, T; Isaacs, J; Jaffer, A; Amante, Ej; Jeka, S; Jimenez, R; Jones, G; Jones, R; Kaine, J; Kashif, A; Kaufmann, C; Kay, J; Khraishi, M; Kivitz, A; Klinkhoff, A; Kraag, G; Krystufkova, O; Kucharz, E; Lawson, J; Leirisalo Repo, M; Levin, R; Liang, G; Liang, P; Limonta, M; Lowenstein, M; Rodriguez Lozano, C; Lue, C; Mahowald, M; Maradiaga, M; Maricic, M; Mariette, X; Martin, L; Massarotti, E; Matucci Cerinic, M; Montecucco, Cm; Mazurov, V; Mcnally, J; Mehta, D; Meyer, O; Misra, R; Moreland, Lw; Mueller Ladner, U; Myerson, G; Nasonov, E; Navarra, S; Navarro, F; Neal, N; Olech, E; Olsen, N; Pablos, Jl; Pacheco, C; Pal, S; Palomo, Er; Pandith, V; Penserga, Eg; Prupas, H; Radominski, S; Ramos Remus, C; Reid, D; Riordan, K; Rosenberg, D; Ruiz, A; Saadeh, C; Salvarani, Carlo; Samuels, A; Sanmarti, R; Sarzi Puttini, P; Saxe, P; Schechtman, J; Scoville, C; Sedlackova, M; Sedrish, M; Sejer Hansen, M; Sibilia, J; Siebert, S; Specker, C; Stern, S; Szechinski, J; Tahir, H; Taylor, A; Thompson, Pw; Tony, Hp; Tornero, J; Trapp, R; Tremblay, Jl; Valesini, G; Van Den Bosch, F; Wanchu, A; Wassenberg, S; Ximenes, Ac; Kim, Hy; Zanetakis, E; Zazueta, B; Zerbini, C.

doi:10.1136/ard.2010.137703

Rituximab is an effective treatment in patients with established rheumatoid arthritis (RA). The objective of the IMAGE study was to determine the efficacy of rituximab in the prevention of joint damage and its safety in combination with methotrexate (MTX) in patients initiating treatment with MTX.

Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial / Tak, P.p., Rigby, W.f., Rubbert Roth, A., Peterfy, C.g., Van Vollenhoven, R.f., Stohl, W., Hessey, E., Chen, A., Tyrrell, H., Shaw, T.m., Aelion J, I.I.N.V.E.S.T.I.G.A.T.O.R.S., Afif, N., Ahmadi, F., Aires, F., Alanis, E., Alonso, C.s., Alten, R.h., Alvaro Gracia, J.m., Ashrafzadeh, A., Ballina, J., et al.. - In: ANNALS OF THE RHEUMATIC DISEASES. - ISSN 0003-4967. - 70:1(2011), pp. 39-46. [10.1136/ard.2010.137703]