Giant cell (temporal) arteritis (GCA) is a vasculitis that mainly affects the large and medium arteries, especially the branches of the proximal aorta. Interleukin-32 (IL-32) is a recently described Th1 proinflammatory cytokine, and is mainly induced by interferon-γ (IFNγ), IL-1β, and tumor necrosis factor α (TNFα). This study was undertaken to investigate the expression and tissue distribution of IL-32 in artery biopsy specimens from patients with GCA.
Expression of interleukin-32 in the inflamed arteries of patients with giant cell arteritis / Ciccia, Francesco; Alessandro, Riccardo; Rizzo, Aroldo; Principe, Simona; Raiata, Francesca; Cavazza, Alberto; Guggino, Giuliana; Accardo Palumbo, Antonina; Boiardi, Luigi; Ferrante, Angelo; Principato, Alfonso; Giardina, Annarita; De Leo, Giacomo; Salvarani, Carlo; Triolo, Giovanni. - In: ARTHRITIS AND RHEUMATISM. - ISSN 1529-0131. - 63:(2011), pp. 2097-2104. [10.1002/art.30374]
Expression of interleukin-32 in the inflamed arteries of patients with giant cell arteritis
SALVARANI, CARLO;
2011
Abstract
Giant cell (temporal) arteritis (GCA) is a vasculitis that mainly affects the large and medium arteries, especially the branches of the proximal aorta. Interleukin-32 (IL-32) is a recently described Th1 proinflammatory cytokine, and is mainly induced by interferon-γ (IFNγ), IL-1β, and tumor necrosis factor α (TNFα). This study was undertaken to investigate the expression and tissue distribution of IL-32 in artery biopsy specimens from patients with GCA.
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