Increased expression of IL-33 and its receptor ST2, encoded by the IL1RL1 gene, has been detected in the inflamed arteries of giant cell arteritis (GCA) patients. The aim of the present study was to investigate for the first time the potential influence of the IL33 and IL1RL1 loci on GCA predisposition.
A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA / Márquez, Ana; Solans, Roser; Hernández Rodríguez, José; Cid, Maria C; Castañeda, Santos; Ramentol, Marc; Rodriguez Rodriguez, Luis; Narváez, Javier; Blanco, Ricardo; Ortego Centeno, Norberto; Palm, Oyvind; Diamantopoulos, Andreas P; Braun, Niko; Moosig, Frank; Witte, Torsten; Beretta, Lorenzo; Lunardi, Claudio; Cimmino, Marco A; Vaglio, Augusto; Salvarani, Carlo; González Gay, Miguel A; Martín, Javier. - In: PLOS ONE. - ISSN 1932-6203. - 9:11(2014), pp. e113476-e113476. [10.1371/journal.pone.0113476]
A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA
SALVARANI, CARLO;
2014
Abstract
Increased expression of IL-33 and its receptor ST2, encoded by the IL1RL1 gene, has been detected in the inflamed arteries of giant cell arteritis (GCA) patients. The aim of the present study was to investigate for the first time the potential influence of the IL33 and IL1RL1 loci on GCA predisposition.
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