Several clinical observations have demonstrated a link between heart rate and anxiety or panic disorders. In these patients, β-adrenergic receptor function was altered. This prompted us to investigate whether the β-adrenergic receptor agonist isoproterenol, at a dose that stimulates peripheral β-adrenergic system but has no effects at the central nervous system, can induce anxiety-like behavior in rats. Moreover, some possible messengers involved in the peripheral to brain communication were investigated. Our results showed that isoproterenol (5 mg kg(-1) i.p.) increased heart rate, evoked anxiety-like behavior, did not result in motor impairments and increased extracellular vesicle content in the blood. Plasma corticosterone level was unmodified as well as vesicular Hsp70 content. Vesicular miR-208 was also unmodified indicating a source of increased extracellular vesicles different from cardiomyocytes. We can hypothesize that peripheral extracellular vesicles might contribute to the β-adrenergic receptor-evoked anxiety-like behavior, acting as peripheral signals in modulating the mental state.
Acute isoproterenol induces anxiety-like behavior in rats and increases plasma content of extracellular vesicles / Leo, Giuseppina; Guescini, Michele; Genedani, Susanna; Stocchi, Vilberto; Carone, Chiara; Filaferro, Monica; Sisti, Davide; Marcoli, Manuela; Maura, Guido; Cortelli, Pietro; Guidolin, Diego; Fuxe, Kjell; Agnati, Luigi Francesco. - In: PHYSIOLOGY & BEHAVIOR. - ISSN 0031-9384. - 142(2015), pp. 79-84.
Data di pubblicazione: | 2015 |
Titolo: | Acute isoproterenol induces anxiety-like behavior in rats and increases plasma content of extracellular vesicles |
Autore/i: | Leo, Giuseppina; Guescini, Michele; Genedani, Susanna; Stocchi, Vilberto; Carone, Chiara; Filaferro, Monica; Sisti, Davide; Marcoli, Manuela; Maura, Guido; Cortelli, Pietro; Guidolin, Diego; Fuxe, Kjell; Agnati, Luigi Francesco |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.physbeh.2015.02.002 |
Rivista: | |
Volume: | 142 |
Pagina iniziale: | 79 |
Pagina finale: | 84 |
Codice identificativo ISI: | WOS:000352044000012 |
Codice identificativo Scopus: | 2-s2.0-84922327134 |
Codice identificativo Pubmed: | 25654993 |
Citazione: | Acute isoproterenol induces anxiety-like behavior in rats and increases plasma content of extracellular vesicles / Leo, Giuseppina; Guescini, Michele; Genedani, Susanna; Stocchi, Vilberto; Carone, Chiara; Filaferro, Monica; Sisti, Davide; Marcoli, Manuela; Maura, Guido; Cortelli, Pietro; Guidolin, Diego; Fuxe, Kjell; Agnati, Luigi Francesco. - In: PHYSIOLOGY & BEHAVIOR. - ISSN 0031-9384. - 142(2015), pp. 79-84. |
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