Despite of the several approaches applied to the physicochemical characterization of liposomes, few techniques are really useful to obtain information about the surface properties of these colloidal drug-delivery systems. In this paper, we demonstrate a possible new application of tapping mode atomic force microscopy (AFM) to discriminate between conventional and pegylated liposomes. We showed that the differences on liposomal surface properties revealed by the phase images AFM approach well correlate with the data obtained using classical methods, such as light scattering, hydrodynamic, and nuclear magnetic resonance analysis.

AFM phase imaging of soft-hydrated samples: A versatile tool to complete the chemical-physical study of liposomes / Ruozi, Barbara; Tosi, Giovanni; Tonelli, Massimo; Bondioli, Lucia; Mucci, Adele; Forni, Flavio; Vandelli, Maria Angela. - In: JOURNAL OF LIPOSOME RESEARCH. - ISSN 0898-2104. - STAMPA. - 19:1(2009), pp. 59-67. [10.1080/08982100802584071]

AFM phase imaging of soft-hydrated samples: A versatile tool to complete the chemical-physical study of liposomes

RUOZI, Barbara;TOSI, Giovanni;TONELLI, Massimo;BONDIOLI, Lucia;MUCCI, Adele;FORNI, Flavio;VANDELLI, Maria Angela
2009

Abstract

Despite of the several approaches applied to the physicochemical characterization of liposomes, few techniques are really useful to obtain information about the surface properties of these colloidal drug-delivery systems. In this paper, we demonstrate a possible new application of tapping mode atomic force microscopy (AFM) to discriminate between conventional and pegylated liposomes. We showed that the differences on liposomal surface properties revealed by the phase images AFM approach well correlate with the data obtained using classical methods, such as light scattering, hydrodynamic, and nuclear magnetic resonance analysis.
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AFM phase imaging of soft-hydrated samples: A versatile tool to complete the chemical-physical study of liposomes / Ruozi, Barbara; Tosi, Giovanni; Tonelli, Massimo; Bondioli, Lucia; Mucci, Adele; Forni, Flavio; Vandelli, Maria Angela. - In: JOURNAL OF LIPOSOME RESEARCH. - ISSN 0898-2104. - STAMPA. - 19:1(2009), pp. 59-67. [10.1080/08982100802584071]
Ruozi, Barbara; Tosi, Giovanni; Tonelli, Massimo; Bondioli, Lucia; Mucci, Adele; Forni, Flavio; Vandelli, Maria Angela
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1077189
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