Neuroprotective and neurotrophic properties of leukemia inhibitory factor (LIF) have been widely reported. In the central nervous system (CNS), astrocytes are the major source for LIF, expression of which is enhanced following disturbances leading to neuronal damage. How astrocytic LIF expression is regulated, however, has remained an unanswered question. Since neuronal stress is associated with production of extracellular adenosine, we investigated whether LIF expression in astrocytes was mediated through adenosine receptor signaling.
Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity / Moidunny, Shamsudheen; Vinet, Jonathan; Wesseling, Evelyn; Bijzet, Johan; Shieh, Chu Hsin; van Ijzendoorn, Sven C. D; Bezzi, Paola; Boddeke, Hendrikus W. G. M; Biber, Knut. - In: JOURNAL OF NEUROINFLAMMATION. - ISSN 1742-2094. - 9:(2012), pp. 1-18. [10.1186/1742-2094-9-198]
Adenosine A2B receptor-mediated leukemia inhibitory factor release from astrocytes protects cortical neurons against excitotoxicity
VINET, JONATHAN;
2012
Abstract
Neuroprotective and neurotrophic properties of leukemia inhibitory factor (LIF) have been widely reported. In the central nervous system (CNS), astrocytes are the major source for LIF, expression of which is enhanced following disturbances leading to neuronal damage. How astrocytic LIF expression is regulated, however, has remained an unanswered question. Since neuronal stress is associated with production of extracellular adenosine, we investigated whether LIF expression in astrocytes was mediated through adenosine receptor signaling.
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