Most of the known functions of microglia, including neurotoxic and neuroprotective properties, are attributed to morphologically-activated microglia. Resting, ramified microglia are suggested to primarily monitor their environment including synapses. Here, we show an active protective role of ramified microglia in excitotoxicity-induced neurodegeneration.
Neuroprotective function for ramified microglia in hippocampal excitotoxicity / Vinet, Jonathan; Weering, Hilmar R. J. van; Heinrich, Annette; Kälin, Roland E; Wegner, Anja; Brouwer, Nieske; Heppner, Frank L; Rooijen, Nico van; Boddeke, Hendrikus W. G. M; Biber, Knut. - In: JOURNAL OF NEUROINFLAMMATION. - ISSN 1742-2094. - 9:(2012), pp. 27-1-27-15. [10.1186/1742-2094-9-27]
Neuroprotective function for ramified microglia in hippocampal excitotoxicity
VINET, JONATHAN;
2012
Abstract
Most of the known functions of microglia, including neurotoxic and neuroprotective properties, are attributed to morphologically-activated microglia. Resting, ramified microglia are suggested to primarily monitor their environment including synapses. Here, we show an active protective role of ramified microglia in excitotoxicity-induced neurodegeneration.
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