The CXC chemokine receptor (CXCR) 3 and its chemokines (CXCL9, CXCL10, CXCL11) are involved in the pathogenesis of autoimmune disesases. Under the influence of interferon (IFN) γ, the IFNγ-inducible chemokines are secreted by lymphocytes, and by target cells (fibroblasts, epithelial cells, etc). In target tissues, Th1 lymphocytes are recruited; hence IFNγ is enhanced, which stimulates IFNγ-inducible chemokines (CXCL9, CXCL10, CXCL11) secretion reiterating the autoimmune process. Many studies have evaluated if blockade of ...
Application of Agents Against Interferon-Gamma-Dependent Chemokines in Immunotherapy / Fallahi, Poupak; Ferrari, Silvia Martina; Giuggioli, Dilia; Ferri, Clodoveo; Antonelli, Alessandro. - In: LETTERS IN DRUG DESIGN & DISCOVERY. - ISSN 1570-1808. - 12:9(2015), pp. 696-703. [10.2174/1570180812666150414215616]
Application of Agents Against Interferon-Gamma-Dependent Chemokines in Immunotherapy
FERRARI, Silvia Martina;GIUGGIOLI, DILIA;FERRI, Clodoveo;
2015
Abstract
The CXC chemokine receptor (CXCR) 3 and its chemokines (CXCL9, CXCL10, CXCL11) are involved in the pathogenesis of autoimmune disesases. Under the influence of interferon (IFN) γ, the IFNγ-inducible chemokines are secreted by lymphocytes, and by target cells (fibroblasts, epithelial cells, etc). In target tissues, Th1 lymphocytes are recruited; hence IFNγ is enhanced, which stimulates IFNγ-inducible chemokines (CXCL9, CXCL10, CXCL11) secretion reiterating the autoimmune process. Many studies have evaluated if blockade of ...
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