In this validation study, the predictive value of capillaroscopic skin ulcer risk index (CSURI) in scleroderma patients treated with bosentan has been investigated. Seventy-six consecutive SSc patients treated with bosentan 125 mg bid were enrolled in a multicentre study. The area under the curve was 0.69 (95%CI 0.57-0.79, p=0.0019) and, at the validated cut-off value of 2.96, sensitivity was 86.1%, specificity 60.0%, positive and negative likehood ratio 2.15 and 0.23, while negative and positive predictive values were 82.1% and 64.6%, respectively. CSURI showed a lower negative predictive value in the bosentan group when compared with the control group, while the positive predictive value was similar.

Validation study of predictive value of capillaroscopic skin ulcer risk index (CSURI) in scleroderma patients treated with bosentan / Sebastiani, Marco; Manfredi, Andreina Teresa; Cestelli, Valentina; Praino, Emanuela; Cannarile, Francesca; Giuggioli, Dilia; Colaci, Michele; Ferri, Clodoveo. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - STAMPA. - 33:4 Suppl. 91(2015), pp. 196-196.

Validation study of predictive value of capillaroscopic skin ulcer risk index (CSURI) in scleroderma patients treated with bosentan

SEBASTIANI, Marco;MANFREDI, Andreina Teresa;GIUGGIOLI, DILIA;COLACI, Michele;FERRI, Clodoveo
2015

Abstract

In this validation study, the predictive value of capillaroscopic skin ulcer risk index (CSURI) in scleroderma patients treated with bosentan has been investigated. Seventy-six consecutive SSc patients treated with bosentan 125 mg bid were enrolled in a multicentre study. The area under the curve was 0.69 (95%CI 0.57-0.79, p=0.0019) and, at the validated cut-off value of 2.96, sensitivity was 86.1%, specificity 60.0%, positive and negative likehood ratio 2.15 and 0.23, while negative and positive predictive values were 82.1% and 64.6%, respectively. CSURI showed a lower negative predictive value in the bosentan group when compared with the control group, while the positive predictive value was similar.
2015
5-ago-2015
33
4 Suppl. 91
196
196
Validation study of predictive value of capillaroscopic skin ulcer risk index (CSURI) in scleroderma patients treated with bosentan / Sebastiani, Marco; Manfredi, Andreina Teresa; Cestelli, Valentina; Praino, Emanuela; Cannarile, Francesca; Giuggioli, Dilia; Colaci, Michele; Ferri, Clodoveo. - In: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. - ISSN 0392-856X. - STAMPA. - 33:4 Suppl. 91(2015), pp. 196-196.
Sebastiani, Marco; Manfredi, Andreina Teresa; Cestelli, Valentina; Praino, Emanuela; Cannarile, Francesca; Giuggioli, Dilia; Colaci, Michele; Ferri, C...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1074408
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