BACKGROUND: To characterize the clinical, EEG, and brain imaging findings in an adult case series of patients with de novo refractory status epilepticus (SE) occurring after a febrile illness. METHODS: A retrospective study (2010-2013) was undertaken with the following inclusion criteria: (1) previously healthy adults with refractory SE; (2) seizure onset 0-21 days after a febrile illness; (3) lacking evidence of infectious agents in CSF; (4) no history of seizures (febrile or afebrile) or previous or concomitant neurologic disorder. RESULTS: Among 155 refractory SE cases observed in the study period, 6 patients (17-35 years old) fulfilled the inclusion criteria. Confusion and stupor were the most common symptoms at disease onset, followed after a few days by acute repeated seizures that were uncountable in all but one. Seizures consisted of focal motor/myoclonic phenomena with subsequent generalization. Antiepileptic drugs failed in every patient to control seizures, with all participants requiring intensive care unit admission. Barbiturate coma with burst-suppression pattern was applied in 4 out of 6 patients for 5-14 days. One participant died in the acute phase. In each patient, we observed a reversible bilateral claustrum MRI hyperintensity on T2-weighted sequences, without restricted diffusion, time-related with SE. All patients had negative multiple neural antibodies testing. Four out of 5 surviving patients developed chronic epilepsy. CONCLUSIONS: This is a hypothesis-generating study of a preliminary nature supporting the role of the claustrum in postfebrile de novo SE; future prospective studies are needed to delineate the specificity of this condition, its pathogenesis, and the etiology.
Claustrum damage and refractory status epilepticus following febrile illness / Meletti, Stefano; Slonkova, Jana; Mareckova, Iva; Monti, Giulia; Specchio, Nicola; Hon, Petr; Giovannini, Giada; Marcian, Vaclav; Chiari, Annalisa; Krupa, Petr; Pietrafusa, Nicola; Berankova, Dagmar; Bar, Michal. - In: NEUROLOGY. - ISSN 0028-3878. - STAMPA. - 85:14(2015), pp. 1224-1232. [10.1212/WNL.0000000000001996]
Data di pubblicazione: | 2015 | |
Data di prima pubblicazione: | 4-set-2015 | |
Titolo: | Claustrum damage and refractory status epilepticus following febrile illness | |
Autore/i: | Meletti, Stefano; Slonkova, Jana; Mareckova, Iva; Monti, Giulia; Specchio, Nicola; Hon, Petr; Giovannini, Giada; Marcian, Vaclav; Chiari, Annalisa; Krupa, Petr; Pietrafusa, Nicola; Berankova, Dagmar; Bar, Michal | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1212/WNL.0000000000001996 | |
Rivista: | ||
Volume: | 85 | |
Fascicolo: | 14 | |
Pagina iniziale: | 1224 | |
Pagina finale: | 1232 | |
Codice identificativo ISI: | WOS:000362203200001 | |
Codice identificativo Scopus: | 2-s2.0-84943249282 | |
Codice identificativo Pubmed: | 26341869 | |
Citazione: | Claustrum damage and refractory status epilepticus following febrile illness / Meletti, Stefano; Slonkova, Jana; Mareckova, Iva; Monti, Giulia; Specchio, Nicola; Hon, Petr; Giovannini, Giada; Marcian, Vaclav; Chiari, Annalisa; Krupa, Petr; Pietrafusa, Nicola; Berankova, Dagmar; Bar, Michal. - In: NEUROLOGY. - ISSN 0028-3878. - STAMPA. - 85:14(2015), pp. 1224-1232. [10.1212/WNL.0000000000001996] | |
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