The role of progestogens in Hormone Replacement Therapy (HRT) is to counteract the estrogen- dependent endometrial mitotic stimulation, thus significantly reducing hyperplasia/carcinoma risk of endometrial cells. Progestogens are different for pharmacological potency, secondary effects on other receptors than progestin receptor, and metabolic effect on various tissues (e.g., breast) and systems (e.g., cardiovascular, central nervous system) of the women’s body. This review summarizes current data on progestogen’s pharmacological role in HRT use for menopause management
Progestin compounds in hormone replacemnt therapy / Neri, Manuela; Cornacchia, Stefania; Orrù, Marisa; Corda, Valentina; Malune, Maria Elena; D'Alterio, MAurizio Nicola; Lello, Stefano; Capozzi, Anna; Cagnacci, Angelo; Di Carlo, Costantino; Melis, Gina Benedetto; Paoletti, Anna Maria. - In: MULTIDISCIPLINARY JOURNAL OF WOMEN'S HEALTH.. - ISSN 2281-3403. - STAMPA. - 2:(2013), pp. 44-49.
Progestin compounds in hormone replacemnt therapy
CAGNACCI, Angelo;
2013
Abstract
The role of progestogens in Hormone Replacement Therapy (HRT) is to counteract the estrogen- dependent endometrial mitotic stimulation, thus significantly reducing hyperplasia/carcinoma risk of endometrial cells. Progestogens are different for pharmacological potency, secondary effects on other receptors than progestin receptor, and metabolic effect on various tissues (e.g., breast) and systems (e.g., cardiovascular, central nervous system) of the women’s body. This review summarizes current data on progestogen’s pharmacological role in HRT use for menopause management
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