More than one-fifth of ovarian tumors have hereditary susceptibility and, in about 65–85% of these cases, the genetic abnormality is a germline mutation in BRCA genes. Nevertheless, several other suppressor genes and oncogenes have been associated with hereditary ovarian cancers, including the mismatch repair (MMR) genes in Lynch syndrome, the tumor suppressor gene, TP53, in the Li-Fraumeni syndrome, and several other genes involved in the double-strand breaks repair system, such as CHEK2, RAD51, BRIP1, and PALB2. The study of genetic discriminators and deregulated pathways involved in hereditary ovarian syndromes is relevant for the future development ofmolecular diagnostic strategies and targeted therapeutic approaches.The recent development and implementation of next-generation sequencing technologies have provided the opportunity to simultaneously analyzemultiple cancer susceptibility genes, reduce the delay and costs, and optimize the molecular diagnosis of hereditary tumors. Particularly, the identification of mutations in ovarian cancer susceptibility genes in healthy women may result in a more personalized cancer risk management with tailored clinical and radiological surveillance, chemopreventive approaches, and/or prophylactic surgeries. On the other hand, for ovarian cancer patients, the identification of mutations may provide potential targets for biologic agents and guide treatment decision-making.

Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes / Toss, Angela; Tomasello, Chiara; Razzaboni, Elisabetta; Contu, Giannina; Grandi, Giovanni; Cagnacci, Angelo; Schilder, Russel; Cortesi, Laura. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6141. - 2015:(2015), pp. 1-11. [10.1155/2015/341723]

Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes

TOSS, ANGELA;TOMASELLO, Chiara;RAZZABONI, Elisabetta;GRANDI, GIOVANNI;CAGNACCI, Angelo;CORTESI, LAURA
2015

Abstract

More than one-fifth of ovarian tumors have hereditary susceptibility and, in about 65–85% of these cases, the genetic abnormality is a germline mutation in BRCA genes. Nevertheless, several other suppressor genes and oncogenes have been associated with hereditary ovarian cancers, including the mismatch repair (MMR) genes in Lynch syndrome, the tumor suppressor gene, TP53, in the Li-Fraumeni syndrome, and several other genes involved in the double-strand breaks repair system, such as CHEK2, RAD51, BRIP1, and PALB2. The study of genetic discriminators and deregulated pathways involved in hereditary ovarian syndromes is relevant for the future development ofmolecular diagnostic strategies and targeted therapeutic approaches.The recent development and implementation of next-generation sequencing technologies have provided the opportunity to simultaneously analyzemultiple cancer susceptibility genes, reduce the delay and costs, and optimize the molecular diagnosis of hereditary tumors. Particularly, the identification of mutations in ovarian cancer susceptibility genes in healthy women may result in a more personalized cancer risk management with tailored clinical and radiological surveillance, chemopreventive approaches, and/or prophylactic surgeries. On the other hand, for ovarian cancer patients, the identification of mutations may provide potential targets for biologic agents and guide treatment decision-making.
2015
17-mag-2015
2015
1
11
Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes / Toss, Angela; Tomasello, Chiara; Razzaboni, Elisabetta; Contu, Giannina; Grandi, Giovanni; Cagnacci, Angelo; Schilder, Russel; Cortesi, Laura. - In: BIOMED RESEARCH INTERNATIONAL. - ISSN 2314-6141. - 2015:(2015), pp. 1-11. [10.1155/2015/341723]
Toss, Angela; Tomasello, Chiara; Razzaboni, Elisabetta; Contu, Giannina; Grandi, Giovanni; Cagnacci, Angelo; Schilder, Russel; Cortesi, Laura
File in questo prodotto:
File Dimensione Formato  
Biomed Int.pdf

Open access

Descrizione: pdf
Tipologia: Versione pubblicata dall'editore
Dimensione 1.98 MB
Formato Adobe PDF
1.98 MB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1070647
Citazioni
  • ???jsp.display-item.citation.pmc??? 66
  • Scopus 157
  • ???jsp.display-item.citation.isi??? 135
social impact