Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.
Classification of HHV-6A and HHV-6B as distinct viruses / Ablashi, Dharam; Agut, Henri; Alvarez Lafuente, Roberto; Clark, Duncan A; Dewhurst, Stephen; Diluca, Dario; Flamand, Louis; Frenkel, Niza; Gallo, Robert; Gompels, Ursula A; Höllsberg, Per; Jacobson, Steven; Luppi, Mario; Lusso, Paolo; Malnati, Mauro; Medveczky, Peter; Mori, Yasuko; Pellett, Philip E; Pritchett, Joshua C; Yamanishi, Koichi; Yoshikawa, Tetsushi. - In: ARCHIVES OF VIROLOGY. - ISSN 0304-8608. - STAMPA. - 159:(2014), pp. 863-870. [10.1007/s00705-013-1902-5]
Classification of HHV-6A and HHV-6B as distinct viruses
LUPPI, Mario;
2014
Abstract
Shortly after the discovery of human herpesvirus 6 (HHV-6), two distinct variants, HHV-6A and HHV-6B, were identified. In 2012, the International Committee on Taxonomy of Viruses (ICTV) classified HHV-6A and HHV-6B as separate viruses. This review outlines several of the documented epidemiological, biological, and immunological distinctions between HHV-6A and HHV-6B, which support the ICTV classification. The utilization of virus-specific clinical and laboratory assays for distinguishing HHV-6A and HHV-6B is now required for further classification. For clarity in biological and clinical distinctions between HHV-6A and HHV-6B, scientists and physicians are herein urged, where possible, to differentiate carefully between HHV-6A and HHV-6B in all future publications.
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