Thanks to modern techniques, molecular signatures for melanoma are now identifiable and have opened new horizons in the treatment of metastatic disease with molecular-targeted therapies. We distinguish different melanoma subtypes on the basis of genetic mutations such as BRAFV600E and we can therefore hypothesize the existence of corresponding morphological patterns that might be detected in vivo by noninvasive diagnostic tools such as dermoscopy and confocal microscopy. Eight BRAFV600E mutated melanomas (six primary and two metastases) were collected, matched in terms of age, sex, and thickness wild-type controls, and analyzed. In this preliminary study, regression, corresponding to fibrosis and melanophages in the dermis, was the predominant pattern and was also observed confocally when dermoscopy showed no peppering. In particular, confocal microscopy could not only detect regression but also provided a semiquantitative analysis of its grade through the count of melanophages. Confocal microscopy can be proposed as a useful tool in the preliminary screening and characterization of BRAFV600E mutated melanomas, providing new insights for patients' screening and follow-up.

Confocal microscopy characterization of BRAFV600E mutated melanomas / Ruini, Cristel; Manfredini, Marco; Pellacani, Giovanni; Mandel, Victor Desmond; Tomasi, Aldo; Ponti, Giovanni. - In: MELANOMA RESEARCH. - ISSN 0960-8931. - STAMPA. - 25:4(2015), pp. 367-371. [10.1097/CMR.0000000000000147]

Confocal microscopy characterization of BRAFV600E mutated melanomas

RUINI, Cristel;MANFREDINI, Marco;PELLACANI, Giovanni;MANDEL, Victor Desmond;TOMASI, Aldo;PONTI, Giovanni
2015

Abstract

Thanks to modern techniques, molecular signatures for melanoma are now identifiable and have opened new horizons in the treatment of metastatic disease with molecular-targeted therapies. We distinguish different melanoma subtypes on the basis of genetic mutations such as BRAFV600E and we can therefore hypothesize the existence of corresponding morphological patterns that might be detected in vivo by noninvasive diagnostic tools such as dermoscopy and confocal microscopy. Eight BRAFV600E mutated melanomas (six primary and two metastases) were collected, matched in terms of age, sex, and thickness wild-type controls, and analyzed. In this preliminary study, regression, corresponding to fibrosis and melanophages in the dermis, was the predominant pattern and was also observed confocally when dermoscopy showed no peppering. In particular, confocal microscopy could not only detect regression but also provided a semiquantitative analysis of its grade through the count of melanophages. Confocal microscopy can be proposed as a useful tool in the preliminary screening and characterization of BRAFV600E mutated melanomas, providing new insights for patients' screening and follow-up.
11-lug-2015
25
4
367
371
Confocal microscopy characterization of BRAFV600E mutated melanomas / Ruini, Cristel; Manfredini, Marco; Pellacani, Giovanni; Mandel, Victor Desmond; Tomasi, Aldo; Ponti, Giovanni. - In: MELANOMA RESEARCH. - ISSN 0960-8931. - STAMPA. - 25:4(2015), pp. 367-371. [10.1097/CMR.0000000000000147]
Ruini, Cristel; Manfredini, Marco; Pellacani, Giovanni; Mandel, Victor Desmond; Tomasi, Aldo; Ponti, Giovanni
File in questo prodotto:
File Dimensione Formato  
ruini2015.pdf

non disponibili

Tipologia: Versione dell'editore (versione pubblicata)
Dimensione 296.95 kB
Formato Adobe PDF
296.95 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1069191
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 12
  • ???jsp.display-item.citation.isi??? 11
social impact