TGF-β1 was inversely correlated with E-cadherin but significantly correlated with VEGF. VEGF and AFP had a low coefficient value but statistically significant. A significant correlation was found between E-cadherin and MMP2. In conclusion, TGF-β and E-cadherin are inversely correlated in HCC patients' sera and not related to the BCLC classification nor survival but rather to the biological properties of the tumor.
Circulating TGF-β1-related biomarkers in patients with hepatocellular carcinoma and their association with HCC staging scores / Dituri, Francesco; Serio, Gabriella; Filannino, Doriana; Mascolo, Antonella; Sacco, Rodolfo; Villa, Erica; Giannelli, Gianluigi. - In: CANCER LETTERS. - ISSN 0304-3835. - 353:2(2014), pp. 264-271. [10.1016/j.canlet.2014.07.029]
Circulating TGF-β1-related biomarkers in patients with hepatocellular carcinoma and their association with HCC staging scores
VILLA, Erica;
2014
Abstract
TGF-β1 was inversely correlated with E-cadherin but significantly correlated with VEGF. VEGF and AFP had a low coefficient value but statistically significant. A significant correlation was found between E-cadherin and MMP2. In conclusion, TGF-β and E-cadherin are inversely correlated in HCC patients' sera and not related to the BCLC classification nor survival but rather to the biological properties of the tumor.
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