BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. METHODS: Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarized, and then salient knowledge gaps were identified. RESULTS: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. CONCLUSIONS: Great strides have been made in the diagnosis, assessment, and management of COPD as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered outcomes.

An official American Thoracic Society/European Respiratory Society statement: research questions in chronic obstructive pulmonary disease / Celli, Bartolome R; Decramer, Marc; Wedzicha, Jadwiga A.; Wilson, Kevin C.; Agustí, Alvar; Criner, Gerard J.; Macnee, William; Make, Barry J.; Rennard, Stephen I.; Stockley, Robert A.; Vogelmeier, Claus; Anzueto, Antonio; Au, David H.; Barnes, Peter J.; Burgel, Pierre Regis; Calverley, Peter M.; Casanova, Ciro; Clini, Enrico; Cooper, Christopher B.; Coxson, Harvey O.; Dusser, Daniel J.; Fabbri, Leonardo; Fahy, Bonnie; Ferguson, Gary T.; Fisher, Andrew; Fletcher, Monica J.; Hayot, Maurice; Hurst, John R.; Jones, Paul W.; Mahler, Donald A.; Maltais, François; Mannino, David M.; Martinez, Fernando J.; Miravitlles, Marc; Meek, Paula M.; Papi, Alberto; Rabe, Klaus F.; Roche, Nicolas; Sciurba, Frank C.; Sethi, Sanjay; Siafakas, Nikos; Sin, Don D.; Soriano, Joan B.; Stoller, James K.; Tashkin, Donald P.; Troosters, Thierry; Verleden, Geert M.; Verschakelen, Johny; Vestbo, Jorgen; Walsh, John W.; Washko, George R.; Wise, Robert A.; Wouters, Emiel F. M.; Zuwallack, Richard L.. - In: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. - ISSN 1535-4970. - ELETTRONICO. - 191:7(2015), pp. 4-27.

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