OBJECTIVE: To quantify the impact of organized cervical screening programs (OCSPs) on incidence of invasive cervical cancer (ICC), comparing rates before and after OCSPs' activation. METHODS: This population-based investigation, using individual data from cancer registries and OCSPs, included 3557 women diagnosed with ICC at age 25-74 years in 1995-2008. The year of OCSPs' full-activation was defined as the year when at least 40% of target women had been invited. Incidence rate ratios (IRRs) with 95% confidence intervals (95% CIs) were calculated as the ratios between age-standardized incidence rates observed in periods after OCSPs' full-activation vs those observed in the preceding quinquennium. RESULTS: ICC incidence rates diminished with time since OCSPs' full-activation: after 6-8 years, the IRR was 0.75 (95%CI: 0.67-0.85). The reduction was higher for stages IB-IV (IRR=0.68, 95%CI: 0.58-0.80), squamous cell ICCs (IRR=0.74, 95%CI: 0.64-0.84), and particularly evident among women aged 45-74 years. Conversely, incidence rates of micro-invasive (stage IA) ICCs increased, though not significantly, among women aged 25-44 years (IRR=1.34, 95%CI: 0.91-1.96). Following OCSPs' full-activation, micro-invasive ICCs were mainly and increasingly diagnosed within OCSPs (up to 72%). CONCLUSION(S): Within few years from activation, organized screening positively impacted the already low ICC incidence in Italy and favored down-staging.
|Data di pubblicazione:||2015|
|Titolo:||Changes in cervical cancer incidence following the introduction of organized screening in italy|
|Autori:||Serraino, Diego; Gini, Andrea; Taborelli, Martina; Ronco, Guglielmo; Giorgi-Rossi, Paolo; Zappa, Marco; Crocetti, Emanuele; Franzo, Antonella; Falcini, Fabio; Visioli, Carmen-Beatriz; Stracci, Fabrizio; Zorzi, Manuel; Federico, Massimo; Michiara, Maria; Fusco, Mario; Ferretti, Stefano; Pannozzo, Fabio; Tisano, Francesco; Zanetti, Roberto; Zucchetto, Antonella|
|Digital Object Identifier (DOI):||10.1016/j.ypmed.2015.01.034|
|Appare nelle tipologie:||Articolo su rivista|
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