We performed an external and multicentric validation of the predictive value of abdominal computed tomography (aCT) on time to first treatment (TTFT) in early stage chronic lymphocytic leukemia (CLL) patients. METHODS: aCT was performed at diagnosis in 181 Rai 0 patients enrolled in the O-CLL1-GISL trial (clinicaltrial.gov ID:NCT00917549). RESULTS: Fifty-five patients showed an abnormal aCT. Patients with an abnormal aCT showed a significantly shorter TTFT than those with normal aCT (P < 0.0001). At multivariate analysis, aCT (P = 0.011), β-2 microglobulin (P = 0.019), and CD38 expression (P = 0.047) correlated with TTFT. Following IWCLL 2008 criteria, 112 (61.9%) cases remained at Rai 0, while 69 (38.1%) satisfied the criteria of clinical monoclonal B-cell lymphocytosis (cMBL). Reclassified Rai 0 patients with an abnormal aCT showed a significantly shorter TTFT than those with a normal aCT (P < 0.0001). At multivariate analysis, only aCT (P = 0.011) correlated with TTFT. Eleven cMBL cases (15.9%) showed an abnormal aCT and were reclassified as small lymphocytic lymphomas (SLL); nonetheless, TTFT was similar for cMBLs and SLLs. CONCLUSION: Our results confirm the ability of the abnormal aCT to predict progression in early stage cases.

Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: results of the multicenter O-CLL1-GISL study / Gentile, Massimo; Cutrona, Giovanna; Molica, Stefano; Ilariucci, Fiorella; Mauro, Francesca R; Di Renzo, Nicola; Di Raimondo, Francesco; Vincelli, Iolanda; Todoerti, Katia; Matis, Serena; Musolino, Caterina; Fabris, Sonia; Lionetti, Marta; Levato, Luciano; Zupo, Simona; Angrilli, Francesco; Consoli, Ugo; Festini, Gianluca; Longo, Giuseppe; Cortelezzi, Agostino; Musto, Pellegrino; Federico, Massimo; Neri, Antonino; Ferrarini, Manlio; Morabito, Fortunato. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 0902-4441. - 96(1):(2016), pp. 36-45. [10.1111/ejh.12545]

Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: results of the multicenter O-CLL1-GISL study

FEDERICO, Massimo;
2016

Abstract

We performed an external and multicentric validation of the predictive value of abdominal computed tomography (aCT) on time to first treatment (TTFT) in early stage chronic lymphocytic leukemia (CLL) patients. METHODS: aCT was performed at diagnosis in 181 Rai 0 patients enrolled in the O-CLL1-GISL trial (clinicaltrial.gov ID:NCT00917549). RESULTS: Fifty-five patients showed an abnormal aCT. Patients with an abnormal aCT showed a significantly shorter TTFT than those with normal aCT (P < 0.0001). At multivariate analysis, aCT (P = 0.011), β-2 microglobulin (P = 0.019), and CD38 expression (P = 0.047) correlated with TTFT. Following IWCLL 2008 criteria, 112 (61.9%) cases remained at Rai 0, while 69 (38.1%) satisfied the criteria of clinical monoclonal B-cell lymphocytosis (cMBL). Reclassified Rai 0 patients with an abnormal aCT showed a significantly shorter TTFT than those with a normal aCT (P < 0.0001). At multivariate analysis, only aCT (P = 0.011) correlated with TTFT. Eleven cMBL cases (15.9%) showed an abnormal aCT and were reclassified as small lymphocytic lymphomas (SLL); nonetheless, TTFT was similar for cMBLs and SLLs. CONCLUSION: Our results confirm the ability of the abnormal aCT to predict progression in early stage cases.
31-mar-2015
96(1)
36
45
Prospective validation of predictive value of abdominal computed tomography scan on time to first treatment in Rai 0 chronic lymphocytic leukemia patients: results of the multicenter O-CLL1-GISL study / Gentile, Massimo; Cutrona, Giovanna; Molica, Stefano; Ilariucci, Fiorella; Mauro, Francesca R; Di Renzo, Nicola; Di Raimondo, Francesco; Vincelli, Iolanda; Todoerti, Katia; Matis, Serena; Musolino, Caterina; Fabris, Sonia; Lionetti, Marta; Levato, Luciano; Zupo, Simona; Angrilli, Francesco; Consoli, Ugo; Festini, Gianluca; Longo, Giuseppe; Cortelezzi, Agostino; Musto, Pellegrino; Federico, Massimo; Neri, Antonino; Ferrarini, Manlio; Morabito, Fortunato. - In: EUROPEAN JOURNAL OF HAEMATOLOGY. - ISSN 0902-4441. - 96(1):(2016), pp. 36-45. [10.1111/ejh.12545]
Gentile, Massimo; Cutrona, Giovanna; Molica, Stefano; Ilariucci, Fiorella; Mauro, Francesca R; Di Renzo, Nicola; Di Raimondo, Francesco; Vincelli, Iolanda; Todoerti, Katia; Matis, Serena; Musolino, Caterina; Fabris, Sonia; Lionetti, Marta; Levato, Luciano; Zupo, Simona; Angrilli, Francesco; Consoli, Ugo; Festini, Gianluca; Longo, Giuseppe; Cortelezzi, Agostino; Musto, Pellegrino; Federico, Massimo; Neri, Antonino; Ferrarini, Manlio; Morabito, Fortunato
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1066014
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