The anterior cingulate cortex (ACC)--which plays a role in pain, emotions and behavior--can generate epileptic seizures. To date, little is known on the neuronal mechanisms leading to epileptiform synchronization in this structure. Therefore, we investigated the role of excitatory and inhibitory synaptic transmission in epileptiform activity in this cortical area. In addition, since the ACC presents with a high density of opioid receptors, we studied the effect of opioid agonism on epileptiform synchronization in this brain region.
Epileptiform synchronization in the cingulate cortex / Panuccio, Gabriella; Curia, Giulia; Colosimo, Alfredo; Cruccu, Giorgio; Avoli, Massimo. - In: EPILEPSIA. - ISSN 0013-9580. - STAMPA. - 50:(2009), pp. 521-36-536. [10.1111/j.1528-1167.2008.01779.x]