Alcohol is a major determinant of the outcome of chronic hepatitis C virus (HCV) infection, but self-reported drinking habits lack reliability. We hypothesized that carriage of high-repetition variants (HRV) of the variable number of tandem repeats (VNTR) in exon III of the dopamine receptor D4 gene, linked to binge-drinking and risk-seeking behavior, might be a proxy measure of alcohol consumption, and aimed to verify whether it may affect histologic outcome.
Fibrosis progression in HCV carriers with mild hepatitis who possess the high-repetition variant of the DRD4 gene, a genetic marker for binge-drinking and risk-seeking behavior: a longitudinal study / Minisini, Rosalba; Boccato, Elisa; Favretto, Serena; Alaimo, Emanuele; Smirne, Carlo; Burlone, Michela E; Bocchetta, Simone; Vandelli, Carmen; Colletta, Cosimo; Colletta, Alessandro; Pirisi, Mario. - In: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. - ISSN 0145-6008. - ELETTRONICO. - 37:(2013), pp. 891-895. [10.1111/acer.12047]
Fibrosis progression in HCV carriers with mild hepatitis who possess the high-repetition variant of the DRD4 gene, a genetic marker for binge-drinking and risk-seeking behavior: a longitudinal study
VANDELLI, Carmen;
2013
Abstract
Alcohol is a major determinant of the outcome of chronic hepatitis C virus (HCV) infection, but self-reported drinking habits lack reliability. We hypothesized that carriage of high-repetition variants (HRV) of the variable number of tandem repeats (VNTR) in exon III of the dopamine receptor D4 gene, linked to binge-drinking and risk-seeking behavior, might be a proxy measure of alcohol consumption, and aimed to verify whether it may affect histologic outcome.
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