Abstract In nine patients with posttransplant Kaposi sarcoma (KS) T-cell responses to human herpesvirus (HHV)-8 latent and lytic antigens, as detected by enzyme-linked-immunospot (Elispot) assay, were absent at disease onset. Virus-specific T-cell responses were detected in six renal recipients at remission after a reduction of calcineurin inhibitors (CIs), and in two HHV-8 seropositive renal recipients without KS. In two liver recipients undergoing switch from CIs to sirolimus (SRL), normalization of the T-cell repertoire and recovery of both HHV-8-specific effector and memory T lymphocytes were associated with complete KS remission. In a renal recipient undergoing SRL conversion, the early recovery of HHV-8-specific effector but not of memory T lymphocytes, was associated only with partial remission. Neither rejection nor changes in graft function were observed after SRL conversion. HHV-8-specific T-cell responses are required to achieve posttransplant KS remission, and may be restored under SRL, while maintaining effective immunosuppression.

Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis / Mazzaferro, V; Llovet, Jm; Miceli, R; Bhoori, S; Schiavo, M; Mariani, Maria Luisa; Camerini, T; Roayaie, S; Schwartz, Me; Grazi, Gl; Adam, R; Neuhaus, P; Salizzoni, M; Bruix, J; Forner, A; De Carlis, L; Cillo, U; Burroughs, Ak; Troisi, R; Rossi, Massimo; Gerunda, Giorgio Enrico; Lerut, J; Belghiti, J; Boin, I; Gugenheim, J; Rochling, F; Van Hoek, B; Majno, P; Metroticket, Investigator Study Group. - In: THE LANCET ONCOLOGY. - ISSN 1470-2045. - STAMPA. - 10:(2009), pp. 35-43. [10.1016/S1470-2045(08)70284-5]

Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis

MARIANI, Maria Luisa;ROSSI, MASSIMO;GERUNDA, Giorgio Enrico;
2009

Abstract

Abstract In nine patients with posttransplant Kaposi sarcoma (KS) T-cell responses to human herpesvirus (HHV)-8 latent and lytic antigens, as detected by enzyme-linked-immunospot (Elispot) assay, were absent at disease onset. Virus-specific T-cell responses were detected in six renal recipients at remission after a reduction of calcineurin inhibitors (CIs), and in two HHV-8 seropositive renal recipients without KS. In two liver recipients undergoing switch from CIs to sirolimus (SRL), normalization of the T-cell repertoire and recovery of both HHV-8-specific effector and memory T lymphocytes were associated with complete KS remission. In a renal recipient undergoing SRL conversion, the early recovery of HHV-8-specific effector but not of memory T lymphocytes, was associated only with partial remission. Neither rejection nor changes in graft function were observed after SRL conversion. HHV-8-specific T-cell responses are required to achieve posttransplant KS remission, and may be restored under SRL, while maintaining effective immunosuppression.
2009
10
35
43
Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis / Mazzaferro, V; Llovet, Jm; Miceli, R; Bhoori, S; Schiavo, M; Mariani, Maria Luisa; Camerini, T; Roayaie, S; Schwartz, Me; Grazi, Gl; Adam, R; Neuhaus, P; Salizzoni, M; Bruix, J; Forner, A; De Carlis, L; Cillo, U; Burroughs, Ak; Troisi, R; Rossi, Massimo; Gerunda, Giorgio Enrico; Lerut, J; Belghiti, J; Boin, I; Gugenheim, J; Rochling, F; Van Hoek, B; Majno, P; Metroticket, Investigator Study Group. - In: THE LANCET ONCOLOGY. - ISSN 1470-2045. - STAMPA. - 10:(2009), pp. 35-43. [10.1016/S1470-2045(08)70284-5]
Mazzaferro, V; Llovet, Jm; Miceli, R; Bhoori, S; Schiavo, M; Mariani, Maria Luisa; Camerini, T; Roayaie, S; Schwartz, Me; Grazi, Gl; Adam, R; Neuhaus, P; Salizzoni, M; Bruix, J; Forner, A; De Carlis, L; Cillo, U; Burroughs, Ak; Troisi, R; Rossi, Massimo; Gerunda, Giorgio Enrico; Lerut, J; Belghiti, J; Boin, I; Gugenheim, J; Rochling, F; Van Hoek, B; Majno, P; Metroticket, Investigator Study Group
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/1064499
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