Myeloid leukemias are heterogeneous malignancies in morphology, immunophenotype, genetic and epigenetic alterations, and response to therapy. This heterogeneity is thought to depend on the accumulation of secondary mutations enhancing proliferation/survival and/or blocking differentiation in a small subset of leukemia-initiating cells capable of self-renewal. This model of clonal evolution is based on xenotransplantation studies demonstrating that leukemia can be initiated and maintained in immunodeficient mice by a small subset of purified leukemic cells immunophenotypically similar to normal hematopoietic stem cells and is known as the leukemia stem cell model. Since its original formulation, many studies have validated the main conclusion of this model. However, recent data from xenotransplantation studies in more severely immunodeficient mice suggest that imunophenotype and behavior of leukemic stem cells is more heterogeneous and "plastic" than originally thought. We will discuss here the evolution of the leukemia stem cell model and its impact for the therapy of patients with myeloid malignancies.
Leukemia stem cells: Old concepts and new perspectives / Mariani, Samanta A; Calabretta, Bruno. - In: MOLECULAR ASPECTS OF MEDICINE. - ISSN 0098-2997. - STAMPA. - 39(2014), pp. 102-9-109. [10.1016/j.mam.2013.06.003]
Data di pubblicazione: | 2014 | |
Titolo: | Leukemia stem cells: Old concepts and new perspectives | |
Autore/i: | Mariani, Samanta A; Calabretta, Bruno | |
Autore/i UNIMORE: | ||
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.mam.2013.06.003 | |
Rivista: | ||
Volume: | 39 | |
Pagina iniziale: | 102-9 | |
Pagina finale: | 109 | |
Codice identificativo ISI: | WOS:000343377200007 | |
Codice identificativo Scopus: | 2-s2.0-84906961594 | |
Codice identificativo Pubmed: | 23820118 | |
Citazione: | Leukemia stem cells: Old concepts and new perspectives / Mariani, Samanta A; Calabretta, Bruno. - In: MOLECULAR ASPECTS OF MEDICINE. - ISSN 0098-2997. - STAMPA. - 39(2014), pp. 102-9-109. [10.1016/j.mam.2013.06.003] | |
Tipologia | Articolo su rivista |
File in questo prodotto:
Pubblicazioni consigliate

I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris