Colorectal cancers (CRCs) are frequently colonised by colibactin toxin-producing Escherichia coli bacteria that induce DNA damage in host cells and exhibit protumoural activities. Our objective was to identify small molecules inhibiting the toxic effects induced by these colibactin-producing bacteria.
Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria / Cougnoux, Antony; Delmas, Julien; Gibold, Lucie; Faïs, Tiphanie; Romagnoli, Chiara; Robin, Frederic; Cuevas Ramos, Gabriel; Oswald, Eric; Darfeuille Michaud, Arlette; Prati, Fabio; Dalmasso, Guillaume; Bonnet, Richard. - In: GUT. - ISSN 0017-5749. - ELETTRONICO. - 65:2(2016), pp. 278-285. [10.1136/gutjnl-2014-307241]
Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria
PRATI, Fabio;
2016
Abstract
Colorectal cancers (CRCs) are frequently colonised by colibactin toxin-producing Escherichia coli bacteria that induce DNA damage in host cells and exhibit protumoural activities. Our objective was to identify small molecules inhibiting the toxic effects induced by these colibactin-producing bacteria.
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