[(18)F]-labelled choline analogues, such as 2-[(18)F]fluoroethylcholine ((18)FECH), have suggested to be a new class of choline derivatives highly useful for the imaging of prostate and brain tumours. In fact, tumour cells with enhanced proliferation rate usually exhibit an improved choline uptake due to the increased membrane phospholipids biosynthesis. The aim of this study was the development of a high yielding synthesis of (18)FECH. The possibility of shortening the synthesis time by reacting all the reagents in a convenient and rapid one-step reaction was specially considered.
Efficient automated one-step synthesis of 2-[18F]fluoroethylcholine for clinical imaging: optimized reaction conditions and improved quality controls of different synthetic approaches / Asti, Mattia; Farioli, Daniela; Iori, Michele; Guidotti, Claudio; Versari, Annibale; Salvo, Diana. - In: NUCLEAR MEDICINE AND BIOLOGY. - ISSN 0969-8051. - STAMPA. - 37(2012), pp. 309-315.
Data di pubblicazione: | 2012 |
Titolo: | Efficient automated one-step synthesis of 2-[18F]fluoroethylcholine for clinical imaging: optimized reaction conditions and improved quality controls of different synthetic approaches |
Autore/i: | Asti, Mattia; Farioli, Daniela; Iori, Michele; Guidotti, Claudio; Versari, Annibale; Salvo, Diana |
Autore/i UNIMORE: | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.nucmedbio.2009.12.009 |
Rivista: | |
Volume: | 37 |
Pagina iniziale: | 309 |
Pagina finale: | 315 |
Codice identificativo ISI: | WOS:000276551800008 |
Codice identificativo Scopus: | 2-s2.0-77950299829 |
Codice identificativo Pubmed: | 20346870 |
Citazione: | Efficient automated one-step synthesis of 2-[18F]fluoroethylcholine for clinical imaging: optimized reaction conditions and improved quality controls of different synthetic approaches / Asti, Mattia; Farioli, Daniela; Iori, Michele; Guidotti, Claudio; Versari, Annibale; Salvo, Diana. - In: NUCLEAR MEDICINE AND BIOLOGY. - ISSN 0969-8051. - STAMPA. - 37(2012), pp. 309-315. |
Tipologia | Articolo su rivista |
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