Biocytin analogues labelled with indium-111, yttrium-90 and lutetium-177 have shown their effectiveness in the imaging of infections/inflammation in patients with osteomyelitis and function as efficient tools in pretargeted antibody-guided radioimmunotherapy. In this study, the labelling of a biocytin analogue coupled with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), namely, r-BHD, with gallium-68 (68Ga) was optimized, and the quality and stability of the preparations were assessed for clinical use.

Radiosynthesis of 68Ga-labelled DOTA-biocytin (68Ga-r-BHD) and assessment of its pharmaceutical quality for clinical use / Asti, Mattia; Iori, Michele; Erba, Paola A; Atti, Giulia; Farioli, Daniela; Guidotti, Claudio; Versari, Annibale. - In: NUCLEAR MEDICINE COMMUNICATIONS. - ISSN 0143-3636. - STAMPA. - 33(2012), pp. 1179-1187. [10.1097/MNM.0b013e3283573e05]

Radiosynthesis of 68Ga-labelled DOTA-biocytin (68Ga-r-BHD) and assessment of its pharmaceutical quality for clinical use

FARIOLI, DANIELA;
2012

Abstract

Biocytin analogues labelled with indium-111, yttrium-90 and lutetium-177 have shown their effectiveness in the imaging of infections/inflammation in patients with osteomyelitis and function as efficient tools in pretargeted antibody-guided radioimmunotherapy. In this study, the labelling of a biocytin analogue coupled with DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid), namely, r-BHD, with gallium-68 (68Ga) was optimized, and the quality and stability of the preparations were assessed for clinical use.
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Radiosynthesis of 68Ga-labelled DOTA-biocytin (68Ga-r-BHD) and assessment of its pharmaceutical quality for clinical use / Asti, Mattia; Iori, Michele; Erba, Paola A; Atti, Giulia; Farioli, Daniela; Guidotti, Claudio; Versari, Annibale. - In: NUCLEAR MEDICINE COMMUNICATIONS. - ISSN 0143-3636. - STAMPA. - 33(2012), pp. 1179-1187. [10.1097/MNM.0b013e3283573e05]
Asti, Mattia; Iori, Michele; Erba, Paola A; Atti, Giulia; Farioli, Daniela; Guidotti, Claudio; Versari, Annibale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/1064374
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