Genomic complexity can predict the clinical course of patients affected by chronic lymphocytic leukemia (CLL) with a normal FISH. However, large studies are still lacking. Here, we analyzed a large series of CLL patients and also carried out the so far largest comparison of FISH versus single-nucleotide polymorphism (SNP) array in this disease.
Large genomic aberrations detected by SNP array are independent prognosticators of a shorter time to first treatment in chronic lymphocytic leukemia patients with normal FISH / Mian, M; Rinaldi, A; Mensah, A. A; Rossi, D; Ladetto, M; Forconi, F; Marasca, Roberto; Uhr, M; Stussi, G; Kwee, I; Cavalli, F; Gaidano, G; Zucca, E; Bertoni, F.. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - STAMPA. - 24:(2013), pp. 1378-1384. [10.1093/annonc/mds646]
Large genomic aberrations detected by SNP array are independent prognosticators of a shorter time to first treatment in chronic lymphocytic leukemia patients with normal FISH
MARASCA, Roberto;
2013
Abstract
Genomic complexity can predict the clinical course of patients affected by chronic lymphocytic leukemia (CLL) with a normal FISH. However, large studies are still lacking. Here, we analyzed a large series of CLL patients and also carried out the so far largest comparison of FISH versus single-nucleotide polymorphism (SNP) array in this disease.
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